参附注射液联合抗神经梅毒对神经梅毒的疗效及对患者外周血淋巴细胞亚群的影响

发布时间：2018-02-26 02:00

  本文关键词： 参附注射液 神经梅毒 外周血淋巴细胞亚群　出处：《中药材》2015年01期 　论文类型：期刊论文

【摘要】：目的:考察参附注射液联合抗神经梅毒对神经梅毒的疗效及对患者外周血淋巴细胞亚群的影响。方法:收集2010年6月至2014年3月杭州市西溪医院收治的确诊为神经梅毒患者156例,按随机数字法将患者分为2组:对照组77例和观察组79例,对照组给予青霉素G钠治疗,观察组给予青霉素G钠+参附注射液治疗。结果:治疗前,两组各指标差异均无统计学意义。治疗后,与对照组比较,观察组血清CD4+、CD4+/CD8+和NK细胞显著升高(P0.05),脑脊液RPR滴度、脑脊液TPPA阳性例数、脑脊液白细胞数≥10×106/L例数和脑脊液蛋白0.45 g/L例数、MMSE分数显著降低(P0.05),VFT、DS、Stroop和AVLT分数显著升高(P0.05)。结论:神经梅毒处于免疫抑制状态,参附注射液通过增加CD4+/CD8+和NK细胞改善神经梅毒的细胞免疫功能。参附注射液辅助治疗可增强驱梅效果。
[Abstract]:Objective: to investigate the effect of Shenfu injection combined with anti-neurosyphilis on neurosyphilis and its effect on peripheral blood lymphocyte subsets of patients. 156 patients with syphilis, The patients were randomly divided into two groups: the control group (77 cases) and the observation group (79 cases). The control group was treated with penicillin G sodium and the observation group was treated with penicillin G sodium Shenfu injection. After treatment, compared with the control group, the serum levels of CD4 CD4 / CD8 and NK cells in the observation group were significantly higher than those in the control group (P 0.05), the RPR titer of CSF and the number of TPPA positive cases in CSF were significantly increased in the observation group. The number of leukocytes in CSF 鈮，

本文编号：1536034