丹参酮联合光动力疗法治疗重度痤疮31例临床观察

发布时间：2018-02-26 12:29

本文关键词： 丹参酮光动力疗法痤疮　出处：《中国皮肤性病学杂志》2015年08期 　论文类型：期刊论文

【摘要】：目的探讨丹参酮胶囊联合5-氨基酮戊酸光动力疗法(ALA-PDT)治疗重度痤疮的临床疗效和安全性。方法将入选的61例重度痤疮患者随机分为两组,PDT组(30例),给予ALA-PDT治疗;联合组(31例),给予口服丹参酮胶囊,并结合ALA-PDT治疗。两组同时外用甲硝唑凝胶。比较两组患者在治疗后的疗效及不良反应,并随访3个月。结果治疗6,8周后,联合组治疗重度痤疮患者的有效率(78.57%,96.15%)分别高于PDT组(53.57%,72.00%),差异均有统计学意义(P0.05)。结论两组在治疗重度痤疮方面均有明显的疗效;联合组比PDT组在第6,8周时疗效更明显。从某种意义上看,联合组治疗重度痤疮可以缩短治疗疗程,减轻患者经济负担,且安全性更高。
[Abstract]:Objective to investigate the clinical efficacy and safety of tanshinone capsule combined with 5-aminolevulinic acid photodynamic therapy in the treatment of severe acne. Methods Sixty-one patients with severe acne were randomly divided into two groups: ALA-PDT group (n = 30) and ALA-PDT group (n = 30). 31 patients in the combined group were treated with oral tanshinone capsule combined with ALA-PDT. Metronidazole gel was also used externally in the two groups. The curative effect and adverse reactions of the two groups were compared and followed up for 3 months. Results after 68 weeks of treatment, the patients in the two groups were treated with metronidazole gel. The effective rate of treatment of severe acne in the combined group was 78.57 and 96.15), respectively, which was higher than that in the PDT group (53.57 and 72.00), and the difference was statistically significant (P0.050.Conclusion there are obvious curative effects in the treatment of severe acne between the two groups. The therapeutic effect of the combined group was more obvious than that of the PDT group at the 6th week. In a sense, the combined group could shorten the course of treatment for severe acne, reduce the economic burden of the patients, and have higher safety.
【作者单位】：兰州军区兰州总医院;甘肃中医学院;
【基金】：甘肃中医学院研究生创新基金项目(CX2013-16)
【分类号】：R758.733

【参考文献】