光动力联合多西环素治疗头部脓肿性穿掘性毛囊周围炎的疗效观察

发布时间：2018-03-01 03:21

本文关键词： PCAS 多西环素光动力疗法不良反应　出处：《山西医科大学》2017年硕士论文　论文类型：学位论文

【摘要】：目的:通过对比光动力联合多西环素和单用多西环素治疗头部脓肿性穿掘性毛囊周围炎(PCAS)的临床疗效,探讨10%5-氨基酮戊酸光动力疗法(ALA-PDT)联合多西环素治疗PCAS的有效性及安全性。方法:根据入选原则将收集的40例PCAS患者随机分为联合治疗组(20例)和对照组(20例)。对照组:予以服用盐酸多西环素肠溶胶囊0.1g/次,2次/日,连续服用30日。联合治疗组:服用盐酸多西环素肠溶胶囊,方法同对照组,并同时予以ALA-PDT治疗,每10日1次,连续3次。两组均以30日为一疗程,分别在第10、20、30日进行疗效判断及记录不良反应,并于疗程结束后第1、2月进行随访。结果:两组患者的基线资料无显著的统计学差异(P0.05),两组患者在疗程的第10、20、30日的Sartorius评分组间评分比较差异有统计学意义(P0.05);联合治疗组及对照组在疗程第10日的显效率分别为5%、0,差异无统计学意义(P0.05);联合治疗组在疗程第20、30日的显效率分别为31.6%、51.9%,对照组在疗程第20、30日的显效率分别为5%、20%,组间比较差异均有统计学意义(P0.05);联合治疗组在疗程第10、20日治疗的总有效率分别为63.2%、84.2%,对照组在疗程第10、20日治疗的总有效率分别为20.0%、50%,组间效率差异有统计学意义(P0.05);在疗程30日两组总有效率分别为100%、95%,差异无统计学意义(P0.05)。光动力治疗PCAS不良反应主要表现为水肿性红斑、烧灼感、瘙痒、色素沉着等,未见严重不良反应。结论:PDT联合多西环素和单用多西环素治疗PCAS均有较好疗效;联合治疗疗效好,能显著提高患者治疗显效率。10%ALA-PDT治疗PCAS不良反应小。
[Abstract]:Objective: to compare the clinical effects of photodynamic therapy combined with doxycycline and doxycycline alone in the treatment of head abscess perforating perifollicular perifolliculitis (PCAS). To investigate the efficacy and safety of 105-aminolevulinic acid photodynamic therapy combined with doxycycline in the treatment of PCAS. Methods: according to the principle of inclusion, 40 patients with PCAS were randomly divided into two groups: the combined treatment group (n = 20) and the control group (n = 20). Group B: take doxycycline hydrochloride enteric capsule 0.1g / time twice a day, The combined treatment group was treated with doxycycline hydrochloride enteric-coated capsule in the same way as the control group and was treated with ALA-PDT once every 10th for 3 consecutive times. Both groups were treated with 30th as a course of treatment. The therapeutic effects were evaluated and adverse reactions were recorded at the 10th and 20th, 30th, respectively. The results showed that there was no significant difference in baseline data between the two groups (P 0.05), and there was a significant difference between the two groups in the Sartorius score in 30th. The effective rates in the treatment group and the control group on the 10th of the course of treatment were 50.The difference was not statistically significant (P 0.05); the marked effect rate in the combined treatment group was 31.6% and 51.9% in the 20th and 30th courses of treatment, respectively, while in the control group on the 20th and 30th courses of treatment, the effective rate was 50.20%, respectively. The difference between the two groups was poor. The total effective rates in the combined treatment group were 63.2% and 84.2% respectively in the 10th course of treatment and in 20th, respectively. In the control group, the total effective rates were 20.0% and 50% on the 10th course of treatment and 20th, respectively, and the difference between the two groups was statistically significant (P 0.05); in 30th, the total effective rate of the treatment group was higher than that of the control group (P < 0.05), and the total effective rate of the treatment group was significantly higher than that of the control group (P < 0.05). The total effective rates of the group were 100% and 95%, respectively. There was no significant difference between the two groups (P 0.05). The main adverse effects of photodynamic therapy on PCAS were edema erythema. There was no serious adverse reaction. Conclusion the combination of doxycycline and doxycycline has good effect on PCAS. Can significantly improve the effective rate of treatment. 10 ALA-PDT treatment of PCAS adverse reactions.
【学位授予单位】：山西医科大学
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：R753.3

【参考文献】