FOXP3在玫瑰糠疹、扁平苔藓、大斑块型副银屑病及蕈样肉芽肿中的表达及意义

发布时间：2018-03-05 07:06

本文选题：叉头状转录因子P　切入点：调节性T细胞　出处：《山东大学学报(医学版)》2012年02期 　论文类型：期刊论文

【摘要】：目的探讨叉头状转录因子P3(FOXP3)在玫瑰糠疹、扁平苔藓、大斑块型副银屑病及蕈样肉芽肿中的表达及意义。方法采用免疫组织化学EnVision法检测21例玫瑰糠疹、19例扁平苔藓、17例大斑块型副银屑病、22例蕈样肉芽肿及10例正常人皮肤中FOXP3的表达。结果玫瑰糠疹、扁平苔藓皮损中FOXP3+淋巴细胞阳性率与正常人皮肤中的表达差异无统计学意义(P0.05);大斑块型副银屑病与蕈样肉芽肿皮损中FOXP3+淋巴细胞阳性率均高于玫瑰糠疹、扁平苔藓及正常皮肤(P0.05),但其二者之间的表达差异无统计学意义(P0.05)。结论 FOXP3+淋巴细胞阳性率在炎症性皮肤病、有肿瘤发展倾向的炎症性皮肤病及皮肤淋巴瘤中的表达有逐步增高的趋势。其增多可能为肿瘤细胞的免疫逃逸提供了条件,进而促进了肿瘤的发生、发展。
[Abstract]:Objective to investigate the role of forkhead transcription factor P3FXP3 in pityriasis roseus and lichen planus. Methods Immunohistochemical EnVision method was used to detect 21 cases of pityriasis roseus 19 cases of lichen planus 17 cases of large plaque type psoriasis 22 cases of mushroom granuloma and 10 cases of normal. Expression of FOXP3 in human skin. Results pityriasis roseus. The positive rate of FOXP3 lymphocytes in the lesions of lichen planus was not significantly different from that in the normal skin (P 0.05), and the positive rate of FOXP3 lymphocytes in the lesions of large plaque type psoriasis and mycosis fungoides was higher than that in the skin of pityriasis roseus. In lichen planus and normal skin, however, there was no significant difference in the expression of P0.05T between them. Conclusion the positive rate of FOXP3 lymphocytes in inflammatory dermatosis is significant. The expression of inflammatory dermatoses and cutaneous lymphomas with the tendency of tumor development tends to increase gradually, which may provide the condition for the immune escape of tumor cells, and then promote the occurrence and development of tumor.
【作者单位】：山东大学齐鲁医院皮肤科;青岛市中心医疗集团;
【分类号】：R758.63

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