柔润保湿霜联合复方氟米松软膏外用治疗慢性湿疹的临床研究

发布时间：2018-03-06 11:38

本文选题：湿疹　切入点：慢性　出处：《临床皮肤科杂志》2014年07期 　论文类型：期刊论文

【摘要】：目的:评价柔润保湿霜联合复方氟米松软膏外用治疗慢性湿疹的疗效及停药后的复发情况。方法:将125例慢性湿疹患者随机分为2组。试验组63例,采用柔润保湿霜涂于皮损患处,5 min后再用复方氟米松软膏薄层涂于患处;对照组62例,单用复方氟米松软膏薄层涂于患处,2组均每天早晚各使用1次,疗程3周。停药后试验组继续每日早晚各用1次柔润保湿霜,维持2周。于治疗前,治疗第1、2、3周随访评价疗效,停药后第5、8周评估复发情况。结果:治疗3周后,两组湿疹面积及严重度指数(EASI)均值均较治疗前明显下降,试验组明显低于对照组,前者痊愈率及有效率明显高于后者(P0.01);停药后第5、8周对痊愈和显效患者进行复发情况随访,试验组在延长后续护肤治疗2周后复发率明显低于对照组(P0.05),停药8周后,试验组复发率更明显低于对照组(P0.01),以上差异均有统计学意义。结论:柔润保湿霜联合复方氟米松软膏治疗慢性湿疹在提高疗效,减少复发方面优于单用复方氟米松软膏。二者联合应用具有修复皮肤屏障、减少糖皮质激素用量及不良反应、减少复发、提高疗效等作用,值得临床推广。
[Abstract]:Objective: to evaluate the efficacy of Ruorun moisturizing cream combined with compound flumisone ointment in the treatment of chronic eczema and its recurrence. Methods: 125 patients with chronic eczema were randomly divided into two groups: the experimental group (n = 63), the control group (n = 63), and the control group (n = 63). The soft moisturizing cream was applied to the affected part of the skin for 5 min and then the compound flumisone ointment was applied to the affected area after 5 min, while in the control group 62 cases were treated with the compound flumisone ointment thin layer in the affected area once a day in the morning and evening. The treatment course was 3 weeks. The test group continued to use the moisturizing cream once a day in the morning and evening after withdrawal for 2 weeks. Before the treatment, the treatment was followed up for 2 weeks, and the recurrence was evaluated at the 5th week and the 8th week after the treatment. Results: after 3 weeks of treatment, the recurrence rate was evaluated. The mean values of eczema area and severity index (EASI) in both groups were significantly lower than those in the control group, and the recovery rate and effective rate of the former group were significantly higher than that of the latter group (P 0.01). The relapse rate of the experimental group was significantly lower than that of the control group after 2 weeks of prolonged skin care treatment, and 8 weeks after the withdrawal of the drug, the recurrence rate of the treatment group was significantly lower than that of the control group. The recurrence rate in the trial group was significantly lower than that in the control group (P 0.01), and the above differences were statistically significant. Conclusion: the treatment of chronic eczema with Ruorun moisturizing cream combined with compound flumisone ointment can improve the curative effect. The combined use of the two ointment can repair the skin barrier, reduce the dosage of glucocorticoid and adverse reactions, reduce the recurrence and improve the curative effect, and it is worth popularizing in clinic.
【作者单位】：广西壮族自治区民族医院皮肤科;
【分类号】：R758.23

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