特应性皮炎患儿56例外周血25羟基维生素D的检测

发布时间：2018-03-10 12:47

  本文选题：特应性皮炎　切入点：儿童　出处：《中国皮肤性病学杂志》2016年12期 　论文类型：期刊论文

【摘要】：目的观察特应性皮炎(atopic dermatitis,AD)患儿血清25-羟维生素D[25-(OH)Vit D]水平,探讨维生素D水平与儿童AD发病之间的关系以及AD严重程度与维生素D的关系。方法收集56例AD患儿(AD组),采用AD评分(SCORAD)对严重程度进行评分,抽取清晨空腹静脉血,检测血清25-(OH)Vit D水平,同时收集70例健康儿童(对照组)的清晨空腹血清25-(OH)Vit D水平。分别对男和女AD患儿、重度和中度、AD患者和健康对照组以及中度AD患者和健康对照组进行对比研究。结果AD组血清25-(OH)Vit D水平(51.32±18.56)nmol/L显著低于对照组(63.45±18.92)nmol/L(P0.01)。AD组中33例(58.92%)血清25-(OH)Vit D水平低于正常值下限50nmol/L,对照组为14.28%(10/70),两组血清不同浓度25-(OH)Vit D的分布差异有统计学意义(P0.01)。AD评分(SCORAD评分≥40分)的重度AD患儿血清25-(OH)Vit D水平低于(15分≤SCORAD评分40分)中度AD患儿[(44.26±16.93)nmol/L vs.(57.43±17.96)nmol/L,P0.01],男女AD患儿之间没有差异,中度与对照组无差异。结论 AD患儿25-(OH)Vit D水平明显低于健康儿童,而中度AD患儿与健康儿童无差异,推测AD病情加重可能与维生素D水平低下有关。
[Abstract]:Objective to observe the serum levels of 25-hydroxyvitamin D in children with atopic dermatitis A (AD). To explore the relationship between vitamin D level and the incidence of AD in children, and the relationship between AD severity and vitamin D. methods 56 cases of AD patients with AD were collected, the severity of AD was evaluated with AD score SCORAD, and fasting venous blood was extracted in the morning. Serum 25-OHH Vit D levels were measured, and fasting serum 25-OHHit D levels in 70 healthy children (control group) were collected at the same time. Results the serum levels of 25-OHHVit D in AD group were 51.32 卤18.56 nmol / L significantly lower than those in control group (63.45 卤18.92nmol / L, P 0.01g 路AD group, 58.92A). Results the serum levels of 25-OHHVit D in AD group were significantly lower than those in control group (58.92A, P = 58.92.Results) the level of 25-OHHVit D in AD group was significantly lower than that in control group (53.45 卤18.92nmol / L). 50 nmol / L, the control group was 14.28% 10 / 70%. There was a significant difference in the distribution of Vit D between the two groups with different serum concentrations of 25-OHHHHHHHHITD. The serum Vit D level of severe AD patients with severe AD was significantly lower than that of moderate AD patients (15 鈮，

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