梅毒血清固定现象孕妇规范治疗对妊娠及新生儿血清学影响分析

发布时间：2018-03-10 23:13

本文选题：妊娠　切入点：梅毒　出处：《中华医院感染学杂志》2015年19期 　论文类型：期刊论文

【摘要】：目的探讨孕期驱梅治疗对妊娠合并梅毒血清固定现象孕妇妊娠结局以及新生儿血清学指标影响,为临床诊治提供参考。方法选取2011年1月-2013年1月54例妊娠合并梅毒血清固定现象孕妇,按照是否行驱梅治疗分为治疗组与未治疗组各27例,同时选择同期正常孕妇50例为对照组,对比3组孕妇妊娠结局、新生儿预后及婴儿血清学指标。结果治疗组孕妇初次检测非苍白密螺旋体抗原血清试验(RPR)滴度为1∶1、1∶2、1∶4的分布率与未治疗组对比差异无统计学意义;3组孕妇早产、自然流产、死胎、不良新生儿结局发生率相近,对比差异均无统计学意义;治疗组新生儿出生时RPR滴度为1∶1、1∶2、1∶4的分布率与未治疗组对比差异无统计学意义;两组新生儿均在出生后6个月内RPR转阴、12个月内苍白密螺旋体抗体(TPPA)转阴,对比差异均无统计学意义。结论孕期驱梅治疗对妊娠合并梅毒血清固定现象孕妇妊娠结局以及新生儿血清学指标无显著影响。
[Abstract]:Objective to investigate the effect of the treatment of driving plum during pregnancy on the pregnancy outcome of pregnant women with syphilis and the serological indexes of newborns. Methods from January 2011 to January 2013, 54 pregnant women with syphilis were divided into treatment group (n = 27) and untreated group (n = 27). At the same time, 50 normal pregnant women were selected as the control group, and the pregnancy outcomes of the 3 groups were compared. Results the distribution rate of RPRs in the treatment group was 1: 1: 1: 1: 2: 1: 4. There was no significant difference between the treatment group and the untreated group in preterm delivery, spontaneous abortion and stillbirth. The incidence of adverse neonatal outcomes was similar, and there was no significant difference in the distribution of RPR titer at birth between the treatment group and the untreated group. In both groups, RPR turned negative within 6 months after birth and turned negative within 12 months. Conclusion there is no significant difference between pregnancy and syphilis. Conclusion there is no significant effect on pregnancy outcome and neonatal serological index of pregnant women with syphilis.
【作者单位】：温州医科大学附属乐清医院皮肤科;温州医科大学附属第一医院皮肤科;
【基金】：温州市卫生局基金资助项目(2015B62)
【分类号】：R759.15

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