C反应蛋白与慢性自发性荨麻疹患者临床特征的关系

发布时间：2018-03-14 08:42

本文选题：C反应蛋白　切入点：慢性自发性荨麻疹　出处：《中南大学学报(医学版)》2017年02期 　论文类型：期刊论文

【摘要】：目的:探讨慢性自发性荨麻疹患者外周血C反应蛋白(C reactive protein,CRP)水平与疾病严重程度及第二代抗组胺药物治疗效果的关系。方法:对2013年8月至2015年3月在中南大学湘雅医院皮肤科就诊的605例慢性自发性荨麻疹患者的临床资料进行回顾性分析。根据患者疾病严重程度评分下降是否小于50%将患者分为无效组和有效组,利用t检验及Pearson相关分析对患者的疾病严重程度、第二代抗组胺药疗效等临床特征资料与CRP的关系进行分析。结果:在中重度慢性自发性荨麻疹患者中,不同严重程度的患者其CRP水平存在差异(t= 2.715,P0.01);同时,第二代抗组胺药物治疗有效组与无效组患者时,有效组治疗前CRP水平低于无效组[分别为(2.5764±2.5059)和(3.6715±4.7732)mg/d L],差异有统计学意义(t= 2.187,P0.05)。结论:慢性自发性荨麻疹患者治疗前CRP水平可能与疾病严重程度有关,并且在不同疗效的患者间存在差异。
[Abstract]:Objective: to investigate the relationship between the level of C reactive protein (reactive) in peripheral blood of patients with chronic spontaneous urticaria and the severity of the disease and the efficacy of the second generation antihistamine drugs. The clinical data of 605 patients with chronic spontaneous urticaria in Xiangya Hospital were retrospectively analyzed. Patients were divided into invalid group and effective group according to whether the disease severity score decreased less than 50%. T test and Pearson correlation analysis were used to analyze the relationship between the severity of the disease, the curative effect of the second generation antihistamines and CRP. Results: in the patients with moderate and severe chronic spontaneous urticaria, the relationship between the severity of the disease and the curative effect of the second generation antihistamines was analyzed. The CRP level of patients with different severity was different (t = 2.715P 0.01). At the same time, when the second generation antihistamine drugs were used to treat the patients in the effective group and the ineffective group, The level of CRP before treatment in the effective group was lower than that in the ineffective group [2.5764 卤2.5059] and in the ineffective group (3.6715 卤4.7732 mg / dL, respectively), and the difference was statistically significant. Conclusion: the level of CRP in patients with chronic spontaneous urticaria before treatment may be related to the severity of the disease. And there were differences among patients with different therapeutic effects.
【作者单位】：中南大学湘雅医院皮肤科;
【基金】：国家自然科学基金(81673065) 湖南省自然科学基金(2016JJ3170) 2015年中南大学研究生自主探索创新基金(2015zzts292)~~
【分类号】：R758.24

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