男性雄性激素秃发的临床特征回顾性分析

发布时间：2018-03-16 23:22

  本文选题：雄激素性秃发　切入点：代谢综合征　出处：《浙江大学》2010年硕士论文　论文类型：学位论文

【摘要】： 目的：探讨雄激素性脱发(androgenetic alopecia, AGA)男性患者多个可能相关因素的发生率,代谢综合征(metabolic syndmme, MS)、良性前列腺增生(Benign prostatic hyperplasia, BPH)的发生率以及AGA与心血管病危险因素间的关系。方法：选择2001年1月至3月于浙江大学医学院附属第二医院国际保健中心参加体检的符合Norwood-Hamilton分级法I-VII级的63位男性为秃发组,其中选取符合Norwood-Hamilton分级法III V级及以上的顶秃患者43例,为顶秃组。依秃发组的年龄结构在上述无秃顶的体检人员中随机抽取64人,为对照组。收集AGA患者发病年龄、家族史、生活精神因素及疾病史等相关因素,并对其进行分析。并且检测所有人员体质量指数(body mass index, BMI)、总胆固醇、甘油三酯、高密度脂蛋白胆固醇(high density lipopmtein cholesterol, HDL-C)、低密度脂蛋白胆固醇(low density lipopmtein cholesterol, HDL-C).血糖、血尿酸、肝胆B超及前列腺B超等指标,通过比较三组上述指标的差异,分析AGA男性的MS、心血管病危险因素的发生率及聚集性,及其间的相关性分析及BPH的发生率。 结果：(1)63例患者,平均年龄46.19土9.53岁,以40-60为主,大部分患者发病年龄为31-40岁。其中有34例(53.97%)患者的亲属中有AGA患者,以父亲患病的患者例数最多,为22例占34.92%。20.24%的患者压力较大。20.63%的患者嗜好油腻及高热量饮食。36.51%的患者吸烟,34.92%的患者饮酒。15.87%的患者患有高血压病,6.35%的患者患有糖尿病,3.17%的患者患有冠心病。63例患者临床分级以ⅢⅤ级(15.87%)、Ⅳ级(14.29%)和V级(19.05%)为常见。(2)根据三组的检测结果,发现秃发组的BMI为24.88±3.15Kg/m2,显著高于对照组(23.81±2.87Kg／m2),差异有显著性意义(P0.05)；而总胆固醇、甘油三酯、HDL-C.LDL-C.空腹血糖及血尿酸水平差异无显著性意义(P0.05)。顶秃组的BMI为24.85±3.38Kg／m2,总胆固醇为190.02土30.50mg/dl,显著高于对照组(23.81±2.87Kg／m2,179.67土31.97mg/dl),差异有显著性意义(P0.05)；而甘油三酯、HDL-C.LDL-C.空腹血糖及血尿酸无水平差异无显著性意义(P0.05)。(3)在过重、高血糖、血脂紊乱的危险因素中,顶秃组的发生率为89.07%,高于秃发组的77.78%,而两组均高于对照组的73.44%。(4)影像学检查结果提示秃发组9.68%发现脂肪肝,30.65%发现肝内脂质沉积。顶秃组7.14%发现脂肪肝,30.95%发现肝内脂质沉积。两组结果相对于对照组(脂肪肝17.46%,肝内脂质沉积23.81%)均无显著性差异。秃发组BPH发生率为20.51%,顶秃组为12%,相对于对照组(17.24%)无显著性差异。 结论：AGA多为中年发病,为与家族史、生活精神因素及疾病史有关的多因素疾病。AGA患者中顶秃患者MS、心血管病各个危险因素及前列腺增生发生率未明显高于AGA群体。AGA与MS、心血管病有一定的关联。AGA与BPH未发现明显相关性。
[Abstract]:Objective: to investigate the incidence of multiple related factors in androgenetic alopecia (AGA) male patients with androgenetic alopecia. Metabolic syndrome: the incidence of benign prostatic hyperplasia (BPH) and the relationship between AGA and cardiovascular risk factors. Methods: from January 2001 to March, International Health Care, second affiliated Hospital, School of Medicine, Zhejiang University, China. A total of 63 men who were enrolled in the center's physical examination in accordance with the Norwood-Hamilton classification I-VII were alopecia. Among them, 43 patients with alopecia areata with III V grade and above according to Norwood-Hamilton classification were selected as the alopecia group. 64 patients were randomly selected as control group according to the age structure of the alopecia group. The onset age and family history of AGA patients were collected. Life and mental factors, disease history and other related factors were analyzed. Body mass index (BMI), BMI index, total cholesterol, triglyceride, etc. High density lipopmtein cholesterol (HDL-C), high density lipopmtein cholesterol (HDL-C), low density lipoprotein cholesterol (LDL-C), low density lipopmtein cholesterol (HDL-C), blood glucose, serum uric acid, liver and bile B ultrasound and prostate B ultrasound were compared between the three groups. The incidence and agglomeration of cardiovascular risk factors and their correlation with BPH were analyzed in male patients with AGA. Results the average age of 63 patients was 46.19 卤9.53 years old, mainly 40-60 years old. The majority of the patients were 31-40 years old. Among them, 34 cases had AGA patients, and the father had the most cases. 22 patients with 34.922.20.24% patients with high pressure, 20.63% patients with greasy and high-calorie diet, 36.51% patients smoking, 34.92% patients with alcohol, 15.87% patients with hypertension, 6.35% patients with diabetes mellitus, 3.17% patients with coronary heart disease and 63 patients with coronary heart disease. According to the results of the three groups, clinical grade 鈪，

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