新疆地区Kaposi肉瘤59例临床分析

发布时间：2018-03-23 13:57

本文选题：Kaposi肉瘤　切入点：获得性免疫缺陷综合征　出处：《中国皮肤性病学杂志》2017年10期

【摘要】：目的了解新疆地区Kaposi肉瘤(Kaposi's sarcoma,KS)患者的临床特征,探讨最佳治疗方案及其转归的影响因素。方法回顾性分析本院2002年3月-2016年6月诊治的59例KS患者临床资料。结果59例KS患者中,36例经典型KS,22例艾滋病相关型卡波西肉瘤(AIDS-KS),1例医源性KS。以维吾尔族男性为主,与AIDS-KS患者相比,经典型KS患者发病年龄及病程更长,皮损多局限于四肢远端,少见于头面部、躯干及口腔黏膜,少有浅表淋巴结肿大及内脏器官受累。经典型KS患者以放疗及系统免疫治疗为主,AIDS-KS应积极进行高效抗反转录病毒治疗(HAART),必要时可行联合放疗,疗效较好。结论新疆地区经典型KS与AIDS-KS患者临床特征及治疗转归明显不同,KS多见于维吾尔族,经典型KS皮损以四肢远端受累为主,很少累及内脏器官,病变呈相对良性的过程,大多数患者对局部放疗或系统药物治疗有效。AIDS-KS皮损广泛,易累及内脏器官,预后较经典型KS差。
[Abstract]:Objective to investigate the clinical features of Kaposi sarcoma (Kaposis sarcoma) in Xinjiang. Methods the clinical data of 59 KS patients treated in our hospital from March 2002 to June 2016 were analyzed retrospectively. Results among 59 patients with KS, 36 cases with classic KS type and 22 cases with AIDS-related type card were analyzed retrospectively. A case of iatrogenic KSs in AIDS-KSU was reported. The majority of them were Uygur males. Compared with AIDS-KS patients, the onset age and course of classic KS patients were longer. The skin lesions were limited to the distal extremities and were rarely found in the head and face, trunk and oral mucosa. There are few superficial lymphadenopathy and visceral organ involvement. AIDS-KS patients with classical KS should be treated with highly effective antiretrovirals and combined radiotherapy if necessary. Conclusion the clinical characteristics and therapeutic outcome of classical KS and AIDS-KS in Xinjiang are obviously different from those in Uygur nationality. The lesions of classical KS are mainly involved in distal extremities, rarely involving visceral organs, and the lesions are relatively benign. Most of the patients were effective in local radiotherapy or systemic drug therapy. AIDS-KS skin lesions were extensive and easily involved in visceral organs. The prognosis of the patients was worse than that of classical KS.
【作者单位】：新疆医科大学第一附属医院皮肤科;新疆医科大学第一附属医院感染性疾病中心;
【基金】：国家自然科学基金项目(NO81260246)
【分类号】：R739.5

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