恶性淋巴瘤患者继发带状疱疹的危险因素分析

发布时间：2018-03-24 12:15

  本文选题：恶性淋巴瘤　切入点：带状疱疹　出处：《中华医院感染学杂志》2014年17期

【摘要】：目的探讨恶性淋巴瘤患者化疗后继发带状疱疹的危险因素,指导临床预防与控制医院感染的发生。方法选取2002年1月-2012年10月血液科住院的123例恶性淋巴瘤患者,其中发生带状疱疹患者51例作为病例组,无带状疱疹的患者72例,作为对照组,采用病例对照研究方法对恶性淋巴瘤后带状疱疹患者进行分析,先将研究变量做单因素分析,再将有意义的变量进行多因素非条件logistic同归分析。结果带状疱疹患者的发病部位以胸肋神经区和腰腹神经区为主,分别占56.86%和27.45%;带状疱疹患者的临床类型以寻常型为主,占86.27%;单因素分析显示,Ann Arbor分期(Ⅲ、Ⅳ期)、B症状、初诊时原因不明的发热(38℃)、恶性淋巴瘤未缓解状态与恶性淋巴瘤患者带状疱疹发病显著相关(P0.01),而恶性淋巴瘤达缓解状态是具有统计学意义的保护因素(P0.01);进一步行多因素logistic回归分析,恶性淋巴瘤达缓解状态(OR=0.091)、Ann Arbor分期(Ⅰ、Ⅱ期)(OR=0.089)、A症状(OR=0.065)与恶性淋巴瘤患者带状疱疹发病呈负相关(P0.05)。结论医师应关注恶性淋巴瘤患者发生带状疱疹的危险因素,早期给予积极治疗。
[Abstract]:Objective to investigate the risk factors of secondary herpes zoster after chemotherapy in patients with malignant lymphoma and to guide clinical prevention and control of nosocomial infection. Methods 123 patients with malignant lymphoma were selected from January 2002 to October 2012. Among them, 51 cases of patients with herpes zoster as case group and 72 cases of patients without herpes zoster as control group were used to analyze the patients with herpes zoster after malignant lymphoma by case-control study. Results the main sites of herpes zoster patients were thoracic costal nerve region and lumbar abdominal nerve area, accounting for 56.86% and 27.45%, respectively, and the clinical types of herpes zoster patients were mainly vulgaris. Univariate analysis showed that Ann Arbor stage (鈪，

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