栅栏状嗜中性粒细胞性及肉芽肿性皮炎

发布时间：2018-03-29 20:15

本文选题：皮炎　切入点：栅栏状嗜中性粒细胞性及肉芽肿性　出处：《临床皮肤科杂志》2015年10期

【摘要】：目的:分析栅栏状嗜中性粒细胞性及肉芽肿性皮炎(PNGD)的临床及组织病理学特点。方法:采用回顾性分析方法对9例PNGD患者的临床表现及组织病理特征进行分析。结果:9例PNGD患者,其中男3例,女6例,年龄4~72岁,平均34.33岁;病程6个月~10年,平均3.44年。皮损多位于四肢及躯干,临床上呈多形性表现,包括暗红色斑块、结节、环形红斑、丘疹及带状硬斑等。该病组织病理表现为胶原变性,周围组织细胞浸润,伴嗜中性粒细胞及核尘、淋巴细胞和多核巨细胞浸润,其中4例并发白细胞碎裂性血管炎,6例并发结缔组织病。结论:PNGD是一个病理诊断,临床表现为多形性皮损,组织病理亦呈谱系改变,包括白细胞碎裂性血管炎、栅栏状肉芽肿伴胶原变性、嗜中性粒细胞及核尘、晚期纤维化。临床上需注意其可能并发的潜在性系统性疾病的背景。
[Abstract]:Objective: to analyze the neutrophilic and granulomatous dermatitis paliform (PNGD) clinical and pathological features. Methods: a retrospective analysis of 9 cases of PNGD patients with clinical manifestations and pathological features. Results: 9 cases of PNGD patients, male 3 cases, female 6 cases, age 4~72 years old, average 34.33 years old; the duration of 6 months ~10 years, an average of 3.44 years. The lesions were located in the limbs and trunk, pleomorphic clinical manifestations, including dark red plaques, nodules, annular erythema, papules and hard plaque. The strip disease pathology, collagen degeneration, surrounding tissue infiltration, with neutrophil and lymphocyte nuclear fallout, and multinucleated giant cells, of which 4 cases with leukocytoclastic vasculitis, 6 cases complicated with connective tissue disease. Conclusion: PNGD is a pathological diagnosis, clinical manifestations of pleomorphic lesions and histopathology was also a spectrum of changes, including white blood cells The cell fragmentation vasculitis, palisading granuloma with collagen degeneration, neutrophils and nuclear fallout, advanced fibrosis. Clinical attention should be paid to the potential systemic disease may be complicated by the background.

【作者单位】：第四军医大学西京皮肤医院;
【分类号】：R751

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