特应性皮炎危险因素分析及预测模型建立

发布时间：2018-03-30 18:34

本文选题：特应性皮炎　切入点：危险因素　出处：《广西医科大学学报》2009年05期

【摘要】：目的:探讨特应性皮炎危险因素,为早期预防特应性皮炎提供一种简便、实用的预测方法。方法:共抽取427例新生儿脐血标本,采用免疫荧光法测定脐血IgE含量和用双抗体夹心ELISA法测定IL-5含量,并记录家族过敏史、季节、宠物、皮肤感染、喂养方式、父亲吸烟、居住地、性别等危险因素的情况,随访12个月,追踪观察特应性皮炎患病情况。运用非条件Logis-tic回归筛选危险因素,建立预测模型。结果:①脐血IgE中位数为0.54IU/mL;脐血IL-5均数为5.20pg/mL;标准差为2.14。②从单因素、多因素两方面筛选出脐血IgE、脐血IL-5、家族史为主要危险因素。③建立非条件Logistic回归预测概率模型及预测概率分类图。结论:通过测定婴儿脐血IgE、IL-5水平结合家族过敏史建立预测模型对特应性皮炎发病可进行早期预测。
[Abstract]:Objective: to explore the risk factors of atopic dermatitis and to provide a simple and practical method for early prevention of atopic dermatitis.Methods: a total of 427 neonatal umbilical cord blood samples were collected. The content of IgE in umbilical cord blood was determined by immunofluorescence method and the content of IL-5 was measured by double antibody sandwich ELISA method. The family history of allergies, seasons, pets, skin infections, feeding methods and father smoking were recorded.Risk factors such as residence and sex were followed up for 12 months to observe atopic dermatitis.Non-conditional Logis-tic regression was used to screen risk factors and a predictive model was established.Results the median of IgE in umbilical cord blood was 0.54 IU / mL, the mean of IL-5 in cord blood was 5.20 PG / mL, the standard deviation was 2.14.2 from single factor.Umbilical cord blood IgE, cord blood IL-5 and family history were selected from two aspects of multiple factors. 3. The unconditioned Logistic regression prediction probability model and predictive probability classification map were established.Conclusion: the early prediction of atopic dermatitis can be made by determining the level of IgEN IL-5 in umbilical cord blood and establishing a predictive model combined with the family history of allergy.
【作者单位】：广西医科大学;广西医科大学第三附属医院皮肤科;
【基金】：广西南宁市科研课题基金资助项目(No.20040167C)
【分类号】：R758.23

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