抗生素联合阿维A胶囊治疗寻常型银屑病的疗效分析

发布时间：2018-03-31 01:03

本文选题：寻常型银屑病　切入点：疗效分析　出处：《郑州大学》2014年硕士论文

【摘要】：目的通过对郑州大学第二附属医院皮肤科2013年1月至2014年2月间就诊的163例寻常型银屑病患者病例资料进行临床分析，结合本地区银屑病患者的发病特点，重点分析抗生素联合阿维A胶囊治疗寻常型银屑病的临床疗效和不良反应。方法将收集到的163例寻常性银屑病患者，随机分为治疗组和对照组，其中治疗组82例，对照组81例。两组患者均口服阿维A胶囊，治疗8周为一个疗程；治疗组再加用抗生素治疗，抗生素给予的是注射用头孢硫脒，治疗2周为一个疗程；治疗8周后观察两组之间的临床疗效和不良反应；同时将治疗组的82例患者再分为点滴状银屑病组和斑块状银屑病组，比较两组使用抗生素联合阿维A胶囊治疗效果。皮损治疗后的消退情况，使用PASI评分方法；两组之间的对比均采用SPSS17.0软件，运用秩和检验和χ2检验的分析方法。结果选择的163例患者，男性99例，女性64例，男女比例为1.55:1，平均年龄在42.37±17.23岁。两组在药物治疗前，治疗组的PASI评分为8.86±2.02，对照组的PASI评分为8.75±2.04，两组之间的PASI评分无统计学差异。经过4周的药物治疗后，治疗组的PASI评分为5.73±0.52，对照组的PASI评分为6.97±1.52；经过8周的药物治疗后，治疗组的PASI评分为3.66±0.51，对照组的PASI评分为4.53±1.44，两组治疗前后的PASI评分差异均有统计学意义；药物治疗8周后，治疗组82例寻常性银屑病患者中，有效63例，无效19例，有效率为76.83%；对照组81例寻常性银屑病患者中，有效46例，无效35例，有效率为56.79%。治疗组和对照组的有效率比较，P=0.007，χ2=7.39，差异有统计学意义。治疗组在治疗过程中出现不良反应33例，不良反应发生率为40.24%，对照组在治疗过程中出现不良反应37例，不良反应发生率为45.68%，比较两组之间不良反应发生率差异无统计学意义。将治疗组的82例患者分为点滴状银屑病组和斑块状银屑病组，其中点滴状银屑病47例，斑块状银屑病35例，点滴状银屑病组有效42例，无效5例，有效率为89.36%；斑块状状银屑病组有效22例，无效13例，有效率为62.86%，，点滴状银屑病组和斑块状银屑病组的有效率比较，P=0.004，χ2=8.23，差异有统计学意义。点滴状银屑病组治疗过程中出现不良反应16例，不良反应发生率为38.10%，斑块状银屑病组治疗过程中出现不良反应17例，不良反应发生率为42.50%，两组之间不良反应发生率差异无统计学意义。结论 1.抗生素联合阿维A胶囊治疗寻常型银屑病比单用阿维A胶囊更有效。 2.抗生素联合阿维A胶囊治疗点滴状银屑病比治疗斑块状银屑病疗效更好。
[Abstract]:PurposeThe clinical data of 163 cases of psoriasis vulgaris from January 2013 to February 2014 in the Department of Dermatology, second affiliated Hospital of Zhengzhou University were analyzed.The clinical efficacy and adverse reactions of antibiotics combined with avea capsule in the treatment of psoriasis vulgaris were analyzed.Method163 patients with psoriasis vulgaris were randomly divided into treatment group (n = 82) and control group (n = 81).The patients in both groups were treated with Avera capsule for 8 weeks as a course of treatment, and the treatment group was treated with antibiotics, which were given cefathiramidine for injection and a course of treatment for 2 weeks.After 8 weeks of treatment, the clinical efficacy and adverse reactions between the two groups were observed, and 82 patients in the treatment group were divided into two groups: dripping psoriasis group and plaque psoriasis group.PASI score was used to evaluate the regression of skin lesions after treatment, and the comparison between the two groups was performed with SPSS17.0 software, rank sum test and 蠂 2 test.ResultOf 163 patients, 99 were male and 64 were female. The ratio of male to female was 1.55: 1 with an average age of 42.37 卤17.23 years.Before the treatment, the PASI score of the two groups was 8.86 卤2.02and the PASI score of the control group was 8.75 卤2.04.There was no significant difference in the PASI score between the two groups.After 4 weeks of drug therapy, the PASI score of the treatment group was 5.73 卤0.52, and the PASI score of the control group was 6.97 卤1.52.After 8 weeks of drug therapy, the PASI score of the treatment group was 5.73 卤0.52.The PASI score of the treatment group was 3.66 卤0.51, and the PASI score of the control group was 4.53 卤1.44.The difference of PASI score between the two groups before and after treatment was statistically significant, and after 8 weeks of drug therapy, there were 63 effective cases and 19 ineffective cases in the treatment group in 82 patients with psoriasis vulgaris.The effective rate was 76.83 and the effective rate was 56.79 in the control group of 81 patients with psoriasis vulgaris.The effective rates of the treatment group and the control group were significantly higher than that of the control group (P 0.007, 蠂 2 = 7.39).There were 33 cases of adverse reactions in the treatment group and 37 cases in the control group. The incidence of adverse reactions was 40.24 in the treatment group and 45.68 in the control group. There was no significant difference in the incidence of adverse reactions between the two groups.Eighty-two patients in the treatment group were divided into two groups: droplet psoriasis group (n = 47), plaque psoriasis group (n = 35), droplet psoriasis group (n = 42) and plaque psoriasis group (n = 5).The effective rate was 89.36 and the effective rate was 62.86 in the plaque psoriasis group (n = 22) and in the plaque psoriasis group (n = 13). The effective rate was significantly higher in the droplet psoriasis group and the plaque psoriasis group than in the plaque psoriasis group (P 0.004, 蠂 2 = 8.23).There were 16 cases of adverse reactions in the treatment of psoriasis and 17 cases in the group of plaque psoriasis, and the incidence of adverse reactions was 38.10% in the group of droplet psoriasis and 17 cases in the group of plaque psoriasis.The incidence of adverse reactions was 42.50, and there was no significant difference between the two groups.Conclusion1.Antibiotics combined with Avera capsule were more effective in the treatment of psoriasis vulgaris than Avera capsule alone.2.Antibiotics combined with Avera capsule were more effective in the treatment of plaque psoriasis than in the treatment of plaque psoriasis.
【学位授予单位】：郑州大学
【学位级别】：硕士
【学位授予年份】：2014
【分类号】：R758.63

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