含透明质酸的保湿护肤品治疗面部脂溢性皮炎的临床研究

发布时间：2018-03-31 15:57

本文选题：脂溢性皮炎　切入点：透明质酸　出处：《中国皮肤性病学杂志》2016年04期

【摘要】：目的评估含透明质酸的保湿护肤品(简称:保湿霜)治疗面部脂溢性皮炎(seborrheic dermatitis,SD)的临床疗效、对皮肤屏障功能的影响和安全性。方法 98例SD患者接受保湿霜治疗28d,2次/d。在治疗第0,7,14,28天由皮肤科医生对患者疗效及安全性、患者的满意度进行评估,并测定患者皮肤屏障功能相关指标。结果治疗28d后,患者皮损严重程度评分降低(87.37±15.18)%,94.90%的患者对疗效自评达显著好转或治愈。其中治疗7d后,患者严重程度评分降低(59.84±17.37)%,而52.03%的患者对疗效自评达显著好转或治愈。治疗后,患者皮脂含量从(72.92±21.04)μg/cm2升高至(85.67±19.78)μg/cm2,皮肤平均水含量也从(71.03±2.98)%升高至(73.61±3.13)%。经皮失水(TEWL)从(7.32±1.24)g/(m2.h)降低至(6.44±1.18)g/(m2.h),皮肤的酸碱度和弹性,黑素及血红素含量保持稳定。治疗过程中,只有7例(7.14%)患者有轻微的刺激反应,无1例患者因不良反应而中断治疗。结论保湿霜治疗SD的临床疗效好,且安全性高。
[Abstract]:Objective to evaluate the clinical efficacy of hyaluronic acid moisturizing cream in the treatment of seborrheic dermatitis (SD) of facial seborrheic dermatitis. Methods 98 cases of SD were treated with moisturizing cream for 28 d / d. The dermatologist evaluated the efficacy, safety and satisfaction of the patients on the 7th day of treatment, 1428 days after treatment. Results after 28 days of treatment, the severity score of skin lesion decreased by 87.37 卤15.18% of the patients and 94.90% of the patients achieved significant improvement or cure after 7 days of treatment. The severity score of the patients decreased by 59.84 卤17.37, while 52.03% of the patients achieved significant improvement or cure after treatment. The sebum content increased from 72.92 卤21.04 渭 g/cm2 to 85.67 卤19.78 渭 g / cm ~ 2, and the average water content of the skin increased from 71.03 卤2.98% to 73.61 卤3.13%. The percutaneous dehydration decreased from 7.32 卤1.24 g 路m ~ (2. H) to 6.44 卤1.18 g 路m ~ (2. H). The pH and elasticity of skin, melanin and heme content remained stable. Only 7 patients had mild irritation and none had interrupted treatment because of adverse reactions. Conclusion Moisturizing cream has good clinical efficacy and high safety in the treatment of SD.
【作者单位】：中南大学湘雅一医院;
【基金】：中南大学中央高校基本科研业务费专项资金(2014zzts342)
【分类号】：R758.732

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