降钙素原（PCT）在新生儿脓疱疮合并败血症中的临床应用价值

发布时间：2018-03-31 19:28

  本文选题：降钙素原　切入点：脓疱疮　出处：《暨南大学》2011年硕士论文

【摘要】：目的：探讨降钙素原(PCT)在新生儿脓疱疮合并败血症中的临床应用价值 方法：收集我院2006年1月至2010年12月新生儿科收住的137例新生儿脓疱疮,其中男86例,女51例；足月儿125例,早产儿12例；同期我院新生儿科住院非感染新生儿118例,其中男79例,女39例；足月儿109例,早产儿9例。根据研究目的将上述病例分为三组,新生儿脓疱疮组合并败血症组(A组)9例,按照1987年全国新生儿会议制定的《新生儿败血症诊断标准修订方案》诊断,新生儿脓疱疮组128例(B组)和非感染组(C组)118例。各实验对象均严格无菌采血,立即用200μl血清用半定量固相免疫层析法检测PCT(德国B.R.A.H.M.S Aktiengesellschaft产品)。其中脓疱疮两组(A组,B组)做血培养(美国BD公司儿童血培养瓶)置BACTEC 9050血培养仪内观察结果。两组间计量分析资料采用两样本t检验进行统计分析：计数资料采用χ2检验进行统计分析。 结果：当PCT0.5ng/ml时,新生儿脓疱疮合并新生儿败血症组(A组)与非感染组(C组)相比有显著的统计学意义(P0.01)；当PCT0.5ng/ml时,新生儿脓疱疮组(B组)与非感染组(C组)相比有显著的统计学意义(P0.01)；当PCT2ng/ml时新生儿脓疱疮合并新生儿败血症组(A组)与新生儿脓疱疮组(B组)相比有显著的统计学意义(P0.01)；当PCT2ng/ml时,新生儿脓疱疮组(B组)与非感染组(C组)相比无显著的统计学意义(P0.05)；当PCT2ng/ml时,PCT-Q法与血培养结果比较有显著性差异(P0.01)。 结论：细菌感染时血清PCT早期即升高,当PCT0.5ng/ml时,临床提示存在细菌感染,当PCT2ng/ml时,可作为新生儿脓疱疮合并败血症早期诊断有价值的指标
[Abstract]:Objective: to evaluate the clinical value of procalcitonin (PCT) in neonatal pustular ulcers complicated with septicemia. Methods: from January 2006 to December 2010, 137 neonates with pustular ulcers were collected, including 86 males and 51 females, 125 full-term infants and 12 premature infants. There were 79 males and 39 females, 109 term infants and 9 premature infants. According to the objective of the study, the patients were divided into three groups: group A with neonatal pustular ulcers combined with septicemia (n = 9), and group A (n = 9) with neonatal pustular ulcers combined with septicemia. According to the revised Diagnostic Standard for Neonatal septicemia formulated by the National Conference of Neonates in 1987, 128 cases of neonatal pustular ulcers group (group B) and 118 cases of group C (non-infection group) were diagnosed. The results of blood culture were detected by semi-quantitative solid-phase immunochromatography (semi-quantitative solid-phase immunochromatography) with 200 渭 l serum (German B.R.A.H.M.S Aktiengesellschaft product). The blood culture was performed in group A and B of pustular ulcers. The results were observed by placing BACTEC 9050 blood culture bottle in the blood culture flask of BD company in the United States of America. Two samples t test were used for statistical analysis and 蠂 2 test was used for statistical analysis of counting data. Results: when PCT0.5ng/ml, neonatal pustular ulcers with neonatal septicemia group (group A) was significantly higher than that of non-infection group (group C) (P 0.01), and when PCT0.5ng/ml, there was no significant difference between group A and group C (P < 0.05). Neonatal pustular ulcers group (group B) and non-infection group (group C) (P 0.01); when PCT2ng/ml neonatal pustular ulcers with neonatal septicemia group (group A) compared with neonatal pustular ulcer group (group B) there are significant statistics. When PCT2ng/ml, There was no significant difference between group B and group C in neonatal pustular ulcers (P 0.05), and there was a significant difference between the results of blood culture and that of PCT-Q in PCT2ng/ml. Conclusion: the level of serum PCT increases at the early stage of bacterial infection, and when PCT0.5ng/ml, the clinical results indicate that there is bacterial infection. When PCT2ng/ml, it can be used as a valuable index for the early diagnosis of neonatal pustular ulcers complicated with septicemia.
【学位授予单位】：暨南大学
【学位级别】：硕士
【学位授予年份】：2011
【分类号】：R753.1;R722.1

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