光动力疗法联合改性几丁质治疗尖锐湿疣疗效及HPV基因型分析

发布时间：2018-03-31 22:08

本文选题：尖锐湿疣　切入点：光动力疗法　出处：《中国皮肤性病学杂志》2015年01期

【摘要】：目的观察光动力联合改性几丁质治疗生殖道尖锐湿疣(CA)的疗效、安全性以及治疗后HPV基因型随访。方法将64例生殖道尖锐湿疣患者分两组,每组32例,观察组采用改性几丁质联合光动力治疗3~5次,观察两组疗效、复发率、不良反应等;每例患者首次治疗前,疗程结束时,脱落细胞送检HPV基因亚型。结果观察组和对照组治愈率分别为96.86%和84.36%,差异无统计学意义(P0.05);复发率分别为3.23%和25.93%,不良反应率分别为0和31.25%,差异有统计学意义(P均0.05);两组共8例复发,8例治疗前检查和随访第1次复查均为阳性,第2次、第3次复查仍然有部分病例持续阳性,其中6例为多重型别的高危型感染,随访见高危型HPV33和HPV16持续感染。结论改性几丁质联合光动力治疗对于生殖道尖锐湿疣的患者,可降低其复发率、减少其术后不良反应率;CA患者术后复查检测HPV-DNA的意义更大。
[Abstract]:Objective to observe the efficacy and safety of photodynamic therapy combined with modified chitin in the treatment of genital tract condyloma acuminatum.Methods Sixty-four patients with genital tract condyloma acuminatum were divided into two groups, 32 cases in each group. The observation group was treated with modified chitin and photodynamic therapy for 5 times.Exfoliated cells were examined for HPV gene subtypes.Results the cure rates of the observation group and the control group were 96.86% and 84.36%, respectively, with no significant difference (P 0.05), the recurrence rates were 3.23% and 25.93%, and the adverse reaction rates were 0 and 31.25%, respectively (P < 0.05).The first time of examination and follow-up were all positive.In the second and third reexamination, some cases were still positive, among which 6 cases were multiplex high risk type infection. The follow-up showed high risk HPV33 and HPV16 persistent infection.Conclusion modified chitin combined with photodynamic therapy can reduce the recurrence rate and adverse reaction rate in patients with genital tract condyloma acuminatum.
【作者单位】：南京医科大学第一附属医院皮肤科;
【分类号】：R752.53

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