基于Framingham评分的银屑病患者心血管风险评估

发布时间：2018-04-02 00:06

本文选题：银屑病　切入点：心血管风险　出处：《医学研究生学报》2017年06期

【摘要】：目的银屑病患者发生心血管病的危险因素较普通人群更加常见。文中通过对寻常型银屑病患者和正常体检人群进行Framingham心血管风险评估,旨在讨论银屑病患者心血管病发生风险的特征及防治。方法选取2015年10月至2016年10月期间南京军区南京总医院门诊90例寻常型银屑病患者,其中轻度48名(53.33%)、重度42名(46.67%);并纳入137名正常体检者作为对照。所有寻常型银屑病患者均进行临床和组织病理学诊断,使用银屑病面积和严重程度指数(PASI)评分评估其严重性。检测血脂、血压和空腹血糖等指标,计算未来10年发生心血管病的Framingham风险评分(FRS)。结果寻常型银屑病患者的10年FRS[1(0.5,6.0)]显著高于对照者[0.5(0.5,2.0)],差异有统计学意义(P0.05);10年FRS与性别(r=0.358)、年龄(r=0.678)和病程(r=0.257)呈正相关(P0.05),与病情严重程度无相关性(r=0.184,P0.05)。轻度与重度银屑病患者10年FRS差异无统计学意义(P0.05)。男性患者和50岁以上的老年患者FRS显著增高(P0.05)。结论寻常型银屑病患者尤其是老年男性患者,与正常体检人群相比具有较高的心血管病发生风险。故应对银屑病患者的心血管疾病进行风险评估,并对其并发症进行积极防治。
[Abstract]:Objective the risk factors of cardiovascular disease in psoriasis patients were more common than those in the general population. Framingham cardiovascular risk was assessed in psoriasis vulgaris patients and normal controls. Objective to discuss the risk characteristics and prevention of cardiovascular disease in psoriasis patients. Methods 90 patients with psoriasis vulgaris were selected from October 2015 to October 2016 in Nanjing General Hospital of Nanjing military region. Among them, 48 patients were mild and 46.67.The patients with psoriasis vulgaris were diagnosed clinically and histopathologically. Psoriasis area and severity index (PASI) was used to evaluate the severity of psoriasis. Blood lipids, blood pressure and fasting blood glucose were measured. Results the FRS in 10 years of psoriasis vulgaris was significantly higher than that in the control group (0.5 0. 5 卤2. 0), the difference was statistically significant (P 0. 05); FRS in 10 years had a positive correlation with sex, age, age, and course of disease (P 0. 05, P 0. 257), and was significantly higher than that of controls (P 0. 05, P 0. 05, P 0. 05, P 0. 05, P 0. 05, P 0. 05, P 0. 05, P 0. 05, P 0. 05, P 0. 05, P 0. 05, P 0. 05, P 0. 05). There was no significant difference in FRS between mild psoriasis patients and severe psoriasis patients in 10 years. The FRS levels in male patients and elderly patients over 50 years old were significantly higher than that in patients with psoriasis vulgaris, especially in elderly men. The risk of cardiovascular disease in psoriasis patients should be evaluated and the complications should be actively prevented.
【作者单位】：南方医科大学金陵医院(南京军区南京总医院)皮肤科;
【分类号】：R758.63

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