常规剂量氯雷他定对国人皮肤斑贴试验反应程度的影响

发布时间：2018-04-03 04:32

本文选题：氯雷他定　切入点：斑贴试验　出处：《苏州大学》2011年硕士论文

【摘要】：目的:探究常规剂量氯雷他定对硫酸镍阳性皮肤斑贴试验的影响。方法:采用随机、双盲、对照方法,121个硫酸镍过敏的患者随机分为两组,一组61患者口服氯雷他定片10mg qd ,连续14天,另一组60患者口服安慰剂1片qd ,连续14天。在服药后第11天进行斑贴试验,在服药后第14天判读斑贴试验结果。数据分析在意向性分析人群进行。结果:试验组有55例患者斑贴试验反应程度没有改变,对照组有53例患者斑贴试验反应程度没有改变,两组结果差异没有统计学意义。结论:常规剂量氯雷他定对硫酸镍阳性皮肤斑贴试验反应程度抑制作用有限。
[Abstract]:Objective: to investigate the effect of routine dose of loratadine on nickel sulfate positive skin patch test.Methods: one hundred and twenty-one patients with nickel sulfate allergy were randomly divided into two groups: one group (61 patients) was given 10mg QD for 14 days, the other 60 patients received placebo (QD) for 14 days.Spot patch test was carried out on the 11th day after taking the drug and the results were interpreted on the 14th day after taking the medicine.Data analysis was conducted in intentionality analysis.Results: there were 55 patients in the test group and 53 patients in the control group who had no change in the reaction degree of patch test. The difference between the two groups was not statistically significant.Conclusion: the conventional dose of loratadine has limited inhibitory effect on nickel sulfate positive skin patch test.
【学位授予单位】：苏州大学
【学位级别】：硕士
【学位授予年份】：2011
【分类号】：R758.2

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