麻风病患者外周血IL-10与调节性T细胞的相关性研究
发布时间：2018-04-05 05:27
本文选题：麻风病 切入点：IL- 出处：《中国免疫学杂志》2014年08期
【摘要】：目的:通过检测麻风病患者血清IL-10及外周血CD4+CD25+Foxp3+调节性T细胞(Treg)的水平,分析它们相互间的关系,探讨IL-10及调节性T细胞引起麻风患者免疫功能异常的机制。方法:用流式细胞微球芯片捕获技术(CBA)检测30例麻风患者及25例正常对照血清IL-10的浓度;用流式细胞仪检测51例麻风患者及56例正常对照外周血Treg细胞的水平。结果:麻风患者血清IL-10浓度(130.00±54.27)pg/ml比对照组(15.64±7.11)pg/ml高(P0.05);外周血Treg细胞水平(17.626±8.1977)%比对照组(9.998±1.7062)%高(P0.05);麻风患者治愈后血清IL-10的浓度与外周血Treg细胞水平呈正相关线性关系(P0.05)。结论:IL-10及Treg细胞的调控失衡可能是引起麻风发病的原因之一。
[Abstract]:Aim: to investigate the relationship between serum IL-10 and peripheral blood CD4 CD25 Foxp3 regulatory T cell regs in leprosy patients, and to explore the mechanism of IL-10 and regulatory T cells inducing immune dysfunction in leprosy patients.Methods: the levels of serum IL-10 in 30 leprosy patients and 25 normal controls were detected by flow cytometry microsphere capture technique, and the levels of Treg cells in peripheral blood of 51 leprosy patients and 56 normal controls were detected by flow cytometry.缁撴灉:楹婚鎮ｈ，
本文编号：1713421
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