泛发性脓疱型银屑病82例临床分析

发布时间：2018-04-14 14:28

本文选题：银屑病 + 脓疱　；参考：《中南大学学报(医学版)》2017年02期

【摘要】：目的:分析泛发性脓疱型银屑病(generalized pustular psoriasis,GPP)的临床特征、实验室检查及治疗方法,揭示GPP的发病规律,评估其疗效转归。方法:回顾性分析中南大学湘雅二医院皮肤科82例(16例儿童,66例成人)GPP患者的临床资料。结果:82例GPP患者发病男女之比为1:1.1。无寻常型银屑病史GPP患者(GPP~(PSO ))发病年龄(25.5±21.2)岁,早于有寻常型银屑病史GPP患者(GPP~(PSO+))的(32.7±18.0)岁,GPP~(PSO )住院时间为(12.1±6.7)d,长于GPP~(PSO+)的(11.6±10.2)d。从寻常型银屑病转型至GPP的时间为(77.8±71.9)个月。儿童组以感染(33.3%)和药物(33.3%)为主要诱发因素。成人组GPP~(PSO+)患者以药物诱发(75.0%)为主,而GPP~(PSO )患者主要由感染因素(41.7%)诱发。阿维A治疗效果确切。结论:儿童组及成人组GPP临床特点不尽相同。阿维A可作为GPP的一线药物,同时适用于儿童及成人,慎用激素类药物。
[Abstract]:Objective: to analyze the clinical features, laboratory examination and treatment of generalized pustular psoriasis (GPP), to reveal the pathogenesis of GPP and to evaluate its curative effect.Methods: the clinical data of 82 patients with GPP in 16 children and 66 adults with GPP in Department of Dermatology, Xiangya No.2 Hospital, Central South University were analyzed retrospectively.Results the ratio of male to female in 82 GPP patients was 1: 1.1.The onset age of GPP patients without history of psoriasis vulgaris was 25.5 卤21.2 years old, which was earlier than that of GPP patients with history of psoriasis vulgaris (32.7 卤18.0) years (12.1 卤6.7 days, 11.6 卤10.2 days longer than GPP~(PSO).The time from psoriasis vulgaris to GPP was 77.8 卤71.9 months.In the children's group, infection 33.33.3) and medicine 33.33.3) were the main predisposing factors.In adult group, GPP~(PSO was mainly induced by drug (75.0%), while GPP~(PSO was mainly induced by infection factor (41.7%).Avera is effective in treatment.Conclusion: the clinical features of GPP in children and adults are different.Avera can be used as a first-line drug for GPP, as well as for children and adults.
【作者单位】：中南大学湘雅二医院皮肤性病科;
【基金】：国家自然科学基金(81472881) 湖南省自然科学基金(13JJ1008)~~
【分类号】：R758.63

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