黑素细胞自噬与老年白癜风患者临床类型的关系

发布时间：2018-04-17 17:33

  本文选题：节段型 + 泛发型　； 参考：《中国老年学杂志》2017年23期

【摘要】：目的探讨黑素细胞自噬和老年白癜风患者临床类型的关系。方法选取88例老年白癜风患者,包括41例节段型白癜风患者(节段型组)和47例泛发型白癜风患者(泛发型组),同时选取健康体检的健康老年志愿者88例为对照组。比较节段型组和泛发型组患者的临床特征,比较节段型组和泛发型组白斑区周围正常肤色部位皮肤和对照组任意部位正常肤色皮肤的黑素细胞诱导前后自噬体数量和微管相关蛋白1轻链3(LC3)Ⅱ、小眼球畸形相关转录因子(MITF)、酪氨酸酶相关蛋白(TRPs)相对表达情况。结果节段型组和泛发型组发病年龄、家族史、伴有晕痣和复发率差异无统计学意义(均P0.05);节段型组同形反应少于泛发型组(P0.05)。诱导前节段型组和对照组可见自噬点数目显著多于泛发型组(P0.05);诱导后3组自噬点数目较诱导前均显著增多,且泛发型组显著多于节段型组和对照组,对照组显著多于节段型组(P0.05)。诱导前泛发型组MITF显著高于节段型组和泛发型组,LC3Ⅱ、TYR、TYRP1和TYRP2均显著低于节段型组和泛发型组;诱导后3组MITF、LC3Ⅱ、TYR、TYRP1较诱导前均显著升高,且泛发型组MITF、TYR、TYRP1高于节段型组和泛发型组(P0.05)。结论白癜风患者黑素细胞存在自噬现象,对功能性分子表达产生影响,且泛发型白癜风黑素细胞自噬现象和对功能性分子表达的影响较大。
[Abstract]:Objective to investigate the relationship between melanocyte autophagy and clinical types in elderly patients with vitiligo.Methods 88 elderly patients with vitiligo, including 41 patients with segmental vitiligo (segmental group) and 47 patients with generalized vitiligo (generalized vitiligo) were selected. 88 healthy elderly volunteers were selected as control group.To compare the clinical characteristics between segmental type group and general type group,To compare the number of macrophages and microtubule-associated protein 1 light chain 3C3 (鈪，

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