白芍总苷联合地氯雷他定治疗慢性荨麻疹的meta分析

发布时间：2018-04-23 23:41

本文选题：白芍总苷 + 地氯雷他定　；参考：《辽宁中医药大学》2017年硕士论文

【摘要】：目的:采用meta分析的方法探讨白芍总苷联合地氯雷他定在慢性荨麻疹治疗中的疗效。方法:在万方数字化期刊全文数据库(Wanfang data),相关期刊论文(CNKI),中国生物医学文献数据库(CBM),维普中文科技期刊数据库(VIP)及美国国立医学图书馆(Pub Med)等数据库进行文献检索,在计算机的数据库进行文献检索的同时,结合手工检索图书馆馆藏文献并对学位论文等灰色文献进行检索,文献检索的时间范围为数据库建库日期开始至最后一次检索时间2017年2月20日,在这个时间范围内检索关于白芍总苷或白芍总苷胶囊联合地氯雷他定治疗慢性荨麻疹的随机对照临床试验研究的文献。按照Cochrane系统评价方法,采用RevMan 5.3软件进行Meta分析,比较白芍总苷联合地氯雷他治疗慢性荨麻疹与地氯雷他定单药治疗慢性荨麻疹在治疗的总有效率、治疗的痊愈率、显效率、进步率、无效率、经过治疗3个月后随访观察到慢性荨麻疹的疾病复发率、治疗过程中及治疗后患者发生的不良反应的总发生率、口干、嗜睡、腹泻等不良反应的发生率等结局指标的差异。结果:与采用地氯雷他定单药治疗的慢性荨麻疹患者相比,采用白芍总苷联合地氯雷他定治疗的观察组慢性荨麻疹患者中患者获得的总有效率显著高于对照组(OR=4.53,95%置信区间为2.81-7.29,P0.00001),治愈率显著高于对照组(OR=2.09,95%置信区间为1.45-3.01,P0.0001),显效率显著高于对照组(OR=1.55,95%置信区间=1.04-2.30,P0.05)。且与采用地氯雷他定单药治疗的慢性荨麻疹患者相比,采用白芍总苷联合地氯雷他定治疗的观察组慢性荨麻疹患者中患者获得的复发率显著低于对照组(OR=0.20,95%置信区间为0.11-0.35,P0.00001),不良反应总发生率显著低于对照组(OR=0.56,95%置信区间为0.34-0.92,P=0.02),差异具有统计学意义。结论:白芍总苷联合地氯雷他定对于慢性荨麻疹具有显著的疗效。然而,由于本研究纳入的文献较少且纳入的研究的样本量较少,纳入的研究在研究进行时分组方法、盲法的实施等可能存在偏倚风险。导致本研究的结果可能需要更大样本量的、高质量的研究结果进一步研究证实。
[Abstract]:Objective: to investigate the effect of total paeony glycoside combined with desloratadine in the treatment of chronic urticaria by meta. Methods: literature searches were carried out in Wanfang full text database of Wanfang, CNKI of China, CBMN of Chinese biomedical literature database, VIPB of Weipu Chinese scientific and technological journal and Pub Med. of the National Library of Medicine of the United States of America. At the same time of searching the literature in the database of computer, combining the manual retrieval of the library collection and the retrieval of grey documents, such as degree papers, etc., The time range of document retrieval is from the date of database construction to the time of the last retrieval, February 20, 2017. Literature on randomized controlled clinical trial of total glucoside of paeony or total glucoside of paeony combined with desloratadine in the treatment of chronic urticaria was searched within this time range. According to the evaluation method of Cochrane system and Meta analysis with RevMan 5.3 software, the total effective rate, cure rate and marked rate of total paeony glucoside combined with desloratazone in the treatment of chronic urticaria and desloratazone in the treatment of chronic urticaria were compared. After 3 months of treatment, the recurrence rate of chronic urticaria, the total incidence of adverse reactions during and after treatment, dry mouth, lethargy were observed. Incidence of adverse reactions such as diarrhea and other outcome indicators. Results: compared with patients with chronic urticaria treated with desloratazone, The total effective rate of patients with chronic urticaria in the observation group treated with total glucoside of paeony combined with desloratadine was significantly higher than that in the control group (4.53% 95% confidence interval = 2.81-7.29 P0.00001), and the cure rate was significantly higher than that in the control group (1.45-3.01P0.0001), and the cure rate was significantly higher than that in the control group (1.45-3.01P0.0001). It was significantly higher than that of the control group (1.55% 95% confidence interval, 1.04-2.30) (P 0.05). Compared with patients with chronic urticaria treated with desloratazone, The recurrence rate of patients with chronic urticaria in the observation group treated with total glucoside of paeony combined with desloratadine was significantly lower than that of the control group with 0.2095% confidence interval of 0.11-0.35 P0.00001, and the total incidence of adverse reactions was significantly lower than that of the control group of 0.56% 95% confidence interval. The difference was statistically significant. Conclusion: total glucosides of paeony combined with desloratadine are effective in the treatment of chronic urticaria. However, because the literature involved in this study is less and the sample size of the included research is less, the risk of bias may exist in the research included in the study, such as grouping method and the implementation of blind method. The results of this study may require greater sample size, and high-quality research results are further confirmed.
【学位授予单位】：辽宁中医药大学
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：R758.24

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