地氯雷他定对皮肤斑贴试验阳性等级的影响

发布时间：2018-04-28 13:38

本文选题：地氯雷他定 + 皮肤斑贴试验　；参考：《苏州大学》2012年硕士论文

【摘要】：目的探讨口服地氯雷他定对皮肤斑贴试验阳性等级的影响。方法顺序选取门诊皮肤斑贴试验阳性++患者。第一次斑贴试验后14-69天予地氯雷他定口服，每12小时1次，每次5mg，口服1天（至少2次）后进行第二次斑贴试验，同时继续服药，，共服5天。斑贴试验根据国际接触性皮炎研究组（ICDRG）指南进行操作和判读。斑贴试验反应程度由“-”至“+++”统一转换为数值（0，1，2，3，4）进行统计学分析。结果完成试验的47位受试者，初次斑贴试验共58个格子中变应原显示++阳性反应，经过干预并做第二次斑贴试验后，51个格子仍显示++阳性，4个格子由++变为+阳性，2个格子由++变为+++阳性，1个格子由++变为阴性，两次斑贴试验结果差别无统计学意义(p=0.206)。结论地氯雷他定对皮肤斑贴试验阳性等级结果无影响，其抗炎作用对斑贴试验反应程度的影响甚微。
[Abstract]:Objective to investigate the effect of oral desloratadine on the positive grade of skin patch test. Methods the patients with positive skin patch test were selected in order. Desloratadine was administered 14 to 69 days after the first patch test, once every 12 hours, 5 mg, 1 day (at least 2 times), followed by a second patch test, and continued to take medicine for 5 days. The patch test was performed and interpreted according to the International contact Dermatitis Research Group (ICDRG) guidelines. The response degree of patch test was changed from "-" to "" to the numerical value of "0 ~ (1) ~ (2) ~ (3) ~ (4)). Results among the 47 subjects who completed the experiment, the first patch test showed positive reaction of allergens in 58 lattices. After intervention and the second patch test, 51 lattices were still positive, 4 were positive, 2 were positive, and 1 was negative. There was no statistical difference between the two patch test results. Conclusion desloratadine has no effect on the positive grade of skin patch test, and its anti-inflammatory effect has little effect on the reaction degree of patch test.
【学位授予单位】：苏州大学
【学位级别】：硕士
【学位授予年份】：2012
【分类号】：R758.2

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