IL-17、IL-23在慢性荨麻疹患者外周血中的表达及意义

发布时间：2018-04-28 15:36

本文选题：荨麻疹 + 白介素17　；参考：《华中科技大学》2012年硕士论文

【摘要】：【目的】检测慢性荨麻疹患者外周血中白介素（IL）-17、IL-23表达水平的变化，探讨Th17细胞在慢性荨麻疹发病中的作用。【方法】采用酶联免疫吸附试验方法（ELISA）检测30例慢性荨麻疹患者血清中IL-17和IL-23的表达水平，与30例健康对照组进行比较，并对这两个细胞因子的相关性进行分析。【结果】慢性荨麻疹患者外周血中IL-17、IL-23的浓度水平分别是（403.43±141.61）pg/ml、（243.52±91.86）pg/ml，而正常对照组IL-17、IL-23的浓度分别为（58.31±36.32）pg/ml、（36.52±26.21）pg/ml，IL-17、IL-23在慢性荨麻疹患者组外周血中的表达水平较正常对照组显著升高，差异有统计学意义(P0.05)，并且慢性荨麻疹患者外周血中IL-17与IL-23的表达水平具有明显相关性，，呈正相关。【结论】IL-17、IL-23在慢性荨麻疹患者外周血中高表达，Th17细胞在慢性荨麻疹的发病中发挥一定的免疫作用。
[Abstract]:[objective] to detect the expression of IL-23 in peripheral blood of patients with chronic urticaria and to explore the role of Th17 cells in the pathogenesis of chronic urticaria. [methods] the expression levels of IL-17 and IL-23 in 30 patients with chronic urticaria were detected by Elisa and compared with 30 healthy controls, and the correlation between the two cytokines was analyzed. [results] the levels of IL-17 + IL-23 in the peripheral blood of patients with chronic urticaria were 403.43 卤141.61g / ml, respectively, 243.52 卤91.86pg / ml, and those of normal controls were 58.31 卤36.32 ng / ml, 36.52 卤26.21pgml / ml / ml, respectively, and the expression of IL-17 IL-23 in the peripheral blood of patients with chronic urticaria was significantly higher than that of the control group. The difference was statistically significant (P 0.05), and the expression of IL-17 and IL-23 in peripheral blood of patients with chronic urticaria was positively correlated. [conclusion] the high expression of IL-17 IL-23 in peripheral blood of patients with chronic urticaria may play an immunological role in the pathogenesis of chronic urticaria.
【学位授予单位】：华中科技大学
【学位级别】：硕士
【学位授予年份】：2012
【分类号】：R758.24

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