带状疱疹不同阶段局部一致性脑功能磁共振对比研究

发布时间：2018-05-09 09:40

本文选题：带状疱疹 + 带状疱疹后神经痛　；参考：《中国疼痛医学杂志》2014年10期

【摘要】：目的:利用静息态功能磁共振技术,比较带状疱疹急性期、后遗神经痛期不同阶段大脑神经功能学差异,通过神经影像学来描述带状疱疹引发的疼痛的发生过程,阐述大脑相应激活区域与带状疱疹后神经痛发生的相关性。方法:收集带状疱疹患者12例,其中急性期组6例,后神经痛组6例。扫描前先进行视觉模拟评分法(Visual Analogue Score,VAS)以及SF-MPQ(Short-form of McGill pain questionnaire)评分。随后分组进行fMRI静息态扫描,扫描后通过SPM、REST统计软件处理分析得到局部一致性(Regional Homogeneity,ReHo)数据统计结果。然后分别对比急性期组与后神经痛组的大脑激活区域的差异。结果:对比后神经痛组与急性期组的ReHo结果,前者较后者ReHo值升高的区域有:双侧丘脑、右侧小脑、右侧海马体、右侧梭状回、右侧脑岛。结论:小脑、脑岛、丘脑可能与PHN痛觉过敏形成机制相关;海马体可能参与疼痛记忆的形成。
[Abstract]:Objective: to compare the difference of cerebral nerve function in different stages of herpes zoster acute stage and sequelae neuralgia stage with resting functional magnetic resonance (fMRI), and to describe the process of pain induced by herpes zoster by neuroimaging. The relationship between the corresponding activation regions of the brain and the occurrence of postherpetic neuralgia was discussed. Methods: 12 cases of herpes zoster were collected, including 6 cases in acute stage group and 6 cases in posterior neuralgia group. Visual Analogue score and SF-MPQ(Short-form of McGill pain questionnaire were evaluated before scanning. Then the fMRI resting state scanning was carried out, and the local consistency Regional Homogenicity fMRI data were obtained by the SPM rest statistical software processing and analysis. Then the difference of brain activation area between acute group and posterior neuralgia group was compared. Results: compared with the ReHo results in the acute phase group, the ReHo values of the former group were higher than those of the latter group: bilateral thalamus, right cerebellum, right hippocampal body, right fusiform gyrus and right cerebral island. Conclusion: the cerebellum, island and thalamus may be related to the formation of PHN hyperalgesia, and the hippocampus may be involved in the formation of pain memory.
【作者单位】：广东医学院附属深圳南山医院疼痛科;中科院深圳先进技术研究院;
【分类号】：R752.12

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