rhEGF联合点阵激光对痤疮疤痕患者皮肤屏障功能及TLR2水平的影响

发布时间：2018-05-10 06:05

本文选题：重组人表皮生长因子 + 点阵激光　；参考：《中国现代医学杂志》2017年28期

【摘要】：目的探讨基因重组人表皮生长因子(rhEGF)联合点阵激光对痤疮疤痕患者皮肤屏障功能及Toll样受体2(TLR2)的影响。方法选取2014年1月-2015年12月之间收入该院的60例痤疮疤痕患者为研究对象,根据随机数字法分为对照组和研究组,每组各30例。对照组患者给予点阵超脉冲CO2激光治疗,研究组患者在点阵超脉冲CO2激光治疗后外用rhEGF凝胶。比较两组患者的疗效、外周血CD14~+单核细胞TLR2表达率及皮肤屏障功能。结果两组患者的治疗总有效率比较,差异有统计学意义(P0.05),研究组高于对照组(93.33%vs 70.00%)。治疗后,两组患者的经皮水份丢失(TEWL)、皮肤红斑情况(a值)均较治疗前降低,差异有统计学意义(P0.05),研究组低于对照组;两组患者的pH值较治疗前均降低,差异有统计学意义(P0.05),研究组低于对照组;两组患者的角质层含水量较治疗前均升高,差异有统计学意义(P0.05),研究组高于对照组。治疗后,两组患者的乳酸刺激实验总分、粘脱蛋白质含量较治疗前均降低,差异有统计学意义(P0.05),研究组低于对照组。治疗后,两组患者的TLR2表达率较治疗前均降低,研究组患者低于对照组。研究组患者的瘢痕增生、色素沉着及持久性潮红的发生率低于对照组。结论 rhEGF联合点阵激光对治疗痤疮疤痕具有良好的治疗效果,能够降低TLR2表达水平,改善皮肤屏障功能,减少不良反应,值得临床推广应用。
[Abstract]:Objective to investigate the effects of recombinant human epidermal growth factor (rhEGF) combined with dot array laser on skin barrier function and Toll like receptor 2TLR2 in patients with acne scar. Methods 60 patients with acne scar admitted to our hospital from January 2014 to December 2015 were divided into control group (n = 30) and study group (n = 30). The patients in the control group were treated with dot array superpulse CO2 laser and the patients in the study group were treated with rhEGF gel. The therapeutic effect, the expression rate of CD14 ~ monocyte TLR2 and the skin barrier function were compared between the two groups. Results the total effective rate of the two groups was significantly higher than that of the control group (P 0.05), and the study group was higher than the control group (93.33 vs 70.005). After treatment, the values of percutaneous water loss and skin erythema in the two groups were lower than those before treatment, and the difference was statistically significant (P 0.05), and the pH value of the two groups was lower than that of the control group, and the pH value of the two groups was lower than that of the control group. The difference was statistically significant (P 0.05), which was lower in the study group than that in the control group, and the water content in the cuticle of the two groups was higher than that before treatment, and the difference was statistically significant (P 0.05), which was higher in the study group than in the control group. After treatment, the total score of lactic acid stimulation test and the content of mucilage protein in the two groups were lower than those before treatment, and the difference was statistically significant (P 0.05), and that in the study group was lower than that in the control group. After treatment, the expression rate of TLR2 in both groups was lower than that before treatment, and the expression rate of TLR2 in the study group was lower than that in the control group. The incidence of scar hyperplasia, pigmentation and persistent flashes in the study group was lower than that in the control group. Conclusion rhEGF combined with dot array laser is effective in the treatment of acne scar. It can reduce the expression of TLR2, improve the function of skin barrier and decrease the adverse reaction. It is worth popularizing in clinic.
【作者单位】：上海交通大学附属苏州九龙医院皮肤性病科;山东省滨州医学院附属医院皮肤科;
【分类号】：R758.733

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