秋水仙碱联合窄谱中波紫外线治疗掌跖脓疱病的临床研究

发布时间：2018-05-14 13:50

本文选题：秋水仙碱 + 窄谱中波紫外线　；参考：《基因组学与应用生物学》2017年04期

【摘要】：观察秋水仙碱联合窄谱中波紫外线(NB-UVB)治疗掌跖脓疱病的疗效及对血清肿瘤坏死因子-α(TNF-α)、白细胞介素-8(IL-8)的影响。选择我院皮肤科2011年12月~2015年12月收治的掌趾脓疱病患者88例,按照随机表法将88例患者分为对照组(n=44)和观察组(n=44)。对照组采用NB-UVB照射,隔日1次;观察组采用NB-UVB照射,隔日1次,同时口服秋水仙碱片,两组均连续治疗6周。6周后评价两组临床治疗效果,治疗前后测定患者血清中TNF-α和IL-8的水平,并观察治疗的不良反应。结果显示,治疗6周后,观察组患者的有效率79.5%(35/44)明显高于对照组61.3%(27/44)(p0.05);两组患者治疗前的血清TNF-α、IL-8水平之间对比后无明显差异(p0.05),对照组患者治疗后的血清TNF-α、IL-8水平分别为(10.74±3.25)ng/L和(9.52±2.85)ng/L,观察组分别为(6.24±2.33)ng/L和(5.81±2.20)ng/L,以上指标较治疗前均有显著降低,与对照组相比观察组下降幅度更大(p0.05)。本研究结果表明,秋水仙碱联合NB-UVB照射治疗掌跖脓疱病疗效好,不良反应少,可减少血清中炎症因子TNF-α和IL-8的水平,为治疗掌趾脓疱病提供了新思路。
[Abstract]:To observe the therapeutic effect of colchicine combined with narrow band ultraviolet B (NB-UVB) on palmoplantar pustulosis and the effect of colchicine on serum tumor necrosis factor- 伪 (TNF- 伪) and interleukin-8 (IL-8). From December 2011 to December 2015, 88 patients with metacarpal pustulosis were divided into two groups: control group (n = 88) and observation group (n = 44). The control group was irradiated with NB-UVB once every other day, the observation group was treated with NB-UVB once every other day, and the two groups were given colchicine tablets orally. The two groups were treated continuously for 6 weeks and 6 weeks later to evaluate the clinical effect of the two groups. Serum levels of TNF- 伪 and IL-8 were measured before and after treatment, and adverse reactions were observed. The results showed that, after 6 weeks of treatment, The effective rate of TNF- 伪 -IL-8 in the observation group was significantly higher than that in the control group (79.5% / 44), which was significantly higher than that in the control group (61.3% / 44%), but there was no significant difference in the levels of TNF- 伪 and IL-8 between the two groups before and after treatment. The levels of serum TNF- 伪 IL-8 in the control group were 10.74 卤3.25)ng/L and 9.52 卤2.85 ng / L, respectively, and the levels of TNF- 伪 and IL-8 in the observation group were 6.24 卤2.33)ng/L and 6.24 卤2.85ng/ L, respectively, and those in the control group were 10.74 卤3.25)ng/L and 9.52 卤2.85 ng / L, respectively. 5.81 卤2.20 ng / L, the above indexes were significantly lower than those before treatment. Compared with the control group, the decrease rate of the observation group was greater than that of the control group (P 0.05). The results showed that colchicine combined with NB-UVB irradiation had a good effect on palmoplantar pustulosis with less adverse reactions. It could reduce the levels of TNF- 伪 and IL-8 in serum and provide a new idea for the treatment of palmar toe pustulosis.
【作者单位】：荆州市中心医院;
【基金】：荆州市中心医院皮肤科对本研究的支持
【分类号】：R758.6

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