汉族人群皮肤弹性与年龄和部位的相关性研究

发布时间：2018-05-21 21:36

本文选题：无创性 + 生物力学　；参考：《安徽医科大学》2017年硕士论文

【摘要】：研究背景皮肤生物力学性能的重要特征是皮肤弹性性能,它的大小由皮肤胶原纤维弹力纤维及其数量和排列关系决定。面部皮肤的弹性是皮肤老化的重要指标。近年国外皮肤弹性的研究文献较多,以往活体皮肤弹性测量多针对相对非曝光部位进行。近十年来,皮肤弹性的测量得到了很大的发展,在体测量部位有所增加,并出现了一些新的测量技术。这些技术的原理多基于张力,牵引力、扭力和吸力等,基于吸力原理的测试仪使用较广泛。利用这种测试仪可以研究皮肤的光老化和弹性的关系,还可以研究在生理和病理状况下皮肤弹性的变化规律。Germany CK公司的仪器正是依据负压吸力设计的,负压吸力和皮肤形变是这种设备的测试原理。将皮肤吸进探头的孔径里,一段时间后再释放。被吸进探头内的皮肤深度是由一个光学检测体系获得,这种系统是彼此非接触的。探头内有发光器和收光器和彼此相对的棱镜构成,皮肤的深度与发出光和收到光的比值具有正比关系,在测量过程中皮肤抵抗负压(紧实)以及回到原来状态的能力(弹性)用曲线显示出来(拉伸长度/时间)。Cutometer MPA 580测试程序简便迅速,得到的弹性参数不受皮肤厚度大小的影响,是用来研究皮肤生理性老化和光老化的较好指标。研究目的本研究旨在通过对不同年龄的中国汉族健康人群的无创性皮肤弹性测试,分析其与年龄和部位的相关性,并了解健康人群的皮肤弹性水平,探讨影响皮肤弹性的因素,为其提供有效的预防措施。实验材料与方法用德国CK公司生产的MPA580无创性皮肤弹性测试仪检测669例中国汉族健康志愿者(年龄范围在3-70岁,平均年龄=30.96岁),分别测试前额、左眼角鼻尖、左鼻唇沟、左颈部、左前臂屈侧、脐下、左胫前皮肤弹性。结果非暴露部位皮肤弹性相对于面部暴露部位高;参数R1、R4、R9与年龄呈正相关;弹性总量R2、净弹性量R5、弹性比值R7与年龄呈负相关,眼角部位下降最明显,30岁以后下降加快。眼角、鼻唇沟、颈前区、前臂屈侧R9值随年龄明显增长,颈部R7与年龄的相关性最高,相关系数为0.706。结论本研究首次通过对大样本的健康汉族人群的皮肤弹性测试,建立中国健康汉族人群皮肤弹性数据库,为病理状态下皮肤弹性变化情况提供一个对照平台,对皮肤病的预防、诊断和疗效评估提供基础。为影响皮肤弹性水平的因素提供了依据,而且找到了在体无创性评价皮肤老化程度的简单有效方法,即通过与年龄相关性最高的颈部R7值(弹性比值)(|r|=0.706)的测量,利用线性回归方程来量化皮肤老化程度,及估算皮肤年龄。
[Abstract]:Background the important feature of skin biomechanical properties is skin elasticity, which is made up of collagen fibers. Elastic fibers and their quantity and arrangement are determined. The elasticity of facial skin is an important index of skin aging. In recent years, there have been many researches on skin elasticity in foreign countries. In the past, the measurement of skin elasticity in vivo was mostly carried out on the relatively unexposed site. In the last ten years, the measurement of skin elasticity has been greatly developed, and some new measuring techniques have appeared. The principles of these techniques are based on tension, traction, torsion and suction. This instrument can be used to study the relationship between photoaging and elasticity of skin, as well as the regularity of skin elasticity in physiological and pathological conditions. The instrument of Germany CK Company is designed on the basis of negative suction. Negative suction and skin deformation are the testing principles of this equipment. Suck the skin into the aperture of the probe and release it after a while. The depth of skin absorbed into the probe is obtained by an optical detection system that is non-contact with each other. The probe is composed of a luminator and a light collector and a relative prism. The depth of the skin is proportional to the ratio of the light emitted to the light received. The ability of skin to resist negative pressure (compaction) and to return to its original state (elasticity) was shown by the curve during the measurement. (the test program of stretch length / time, Cutometer MPA 580 was simple and rapid, and the obtained elastic parameters were not affected by the thickness of skin. It is a good index for studying physiologic aging and photoaging of skin. Objective the purpose of this study was to analyze the correlation between noninvasive skin elasticity and age and site of healthy Chinese Han people of different ages, and to explore the factors influencing skin elasticity. To provide effective preventive measures. Materials and methods 669 healthy Chinese Han nationality volunteers (aged 3-70 years, mean age 30.96 years) were tested by MPA580 non-invasive skin elasticity tester made by CK Company in Germany. The forehead, left eye angle and nasal tip, left nasolabial sulcus were measured respectively. Left neck, left forearm flexion, subumbilical, left tibial anterior skin elastic. Results the skin elasticity of the non-exposed area was higher than that of the face exposed site, the parameter R _ (1) C _ (4) C _ (4) C _ (9) was positively correlated with the age, the total elasticity R _ (2), the net elastic value (R _ 5) and the elastic ratio (R _ 7) were negatively correlated with the age, and the decrease of the corner of the eye was more obvious after 30 years. The R9 value of eye angle, nasolabial sulcus, anterior cervical area and forearm flexion increased significantly with age, and the correlation coefficient between neck R7 and age was the highest, the correlation coefficient was 0.706. Conclusion for the first time, the skin elasticity database of healthy Han population in China was established by testing the skin elasticity of a large sample of healthy Han population, which provided a control platform for the change of skin elasticity in pathological condition and the prevention of dermatosis. Diagnosis and evaluation of efficacy provide the basis. It provides the basis for influencing the factors of skin elasticity level, and finds a simple and effective method to evaluate the skin aging degree in vivo, that is, by measuring the cervical R7 value (r = 0.706), which has the highest correlation with age. Linear regression equation was used to quantify skin aging and to estimate skin age.
【学位授予单位】：安徽医科大学
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：R751

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