特异性免疫疗法治疗对粉尘螨过敏的54例慢性荨麻疹临床观察

发布时间：2018-05-22 11:19

本文选题：特异性免疫疗法 + 慢性荨麻疹　；参考：《中国皮肤性病学杂志》2014年02期

【摘要】：目的观察舌下含服标准化粉尘螨滴剂特异性免疫疗法治疗对粉尘螨过敏的慢性荨麻疹患者的临床疗效及安全性。方法将入选的108例对粉尘螨过敏的慢性荨麻疹患者随机分为两组,各54例。治疗组采用标准化粉尘螨滴剂舌下含服免疫治疗,从低剂量起逐步递增至维持剂量,并根据荨麻疹症状控制情况予以咪唑斯叮口服治疗;对照组仅根据荨麻疹症状控制情况予以咪唑斯叮口服治疗。每3个月随访1次,共4次。结果 1年后治疗组有效率(81.48%)优于对照组(53.70%);治疗组服用抗组胺药物评分(0.420±0.189)低于对照组(0.620±0.174),即治疗组较对照组在使用更少的口服抗组胺药的前提下,可以获得更好的症状改善;治疗组的症状改善、服用抗组胺药物及整体满意程度主观评价均明显优于对照组;以上差异均有统计学意义(P均0.05)。治疗组有部分患者出现腹泻、头晕、夜间咳嗽、舌下发麻症状,均未影响治疗。结论特异性免疫疗法对粉尘螨过敏的慢性荨麻疹疗效显著,但治疗期间的不良事件应给予充分关注,其疗效及安全性尚需进一步研究。
[Abstract]:Objective to observe the clinical efficacy and safety of sublingual specific immunotherapy for chronic urticaria with Dermatophagoides farinae hypersensitivity. Methods 108 patients with chronic urticaria who were allergic to Dermatophagoides farinae were randomly divided into two groups: 54 cases each. The treatment group was treated with sublingual immunotherapy with standardized Dermatophagoides farinae drops, which increased gradually from low dose to maintenance dose, and was treated orally with midazolestine according to the symptom control of urticaria. The control group was treated with midazolidine only according to the control of urticaria symptoms. The patients were followed up every 3 months for 4 times. Results after one year, the effective rate of the treatment group was better than that of the control group (53.70), and the score of antihistamine in the treatment group was 0.420 卤0.189) lower than that in the control group (0.620 卤0.174), that is, the treatment group could obtain better symptom improvement under the premise of using less oral antihistamines than the control group. The symptoms of the treatment group were improved, the subjective evaluation of the degree of overall satisfaction and taking antihistamine were significantly better than that of the control group, and the above differences were statistically significant (P < 0.05). In the treatment group, diarrhea, dizziness, nocturnal cough and sublingual anaesthesia did not affect the treatment. Conclusion the effect of specific immunotherapy on chronic urticaria with Dermatophagoides farinae allergy is significant, but the adverse events during treatment should be paid more attention to, and its efficacy and safety should be further studied.
【作者单位】：安徽医科大学附属省立医院、安徽省立医院皮肤性病科;
【分类号】：R758.24

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