IgE及其可溶性高亲和力受体α链与慢性荨麻疹的相关性分析
发布时间：2018-05-24 11:46
本文选题：慢性荨麻疹 + IgE ； 参考：《上海医学》2014年03期
【摘要】：目的测定慢性荨麻疹(CU)患者血清IgE及其可溶性高亲和力受体α链(sFcεRIα)的水平,了解CU与IgE及其受体的相关性。方法分别采用酶联免疫吸附试验、免疫散射比浊法和免疫印迹法测定99例门诊CU患者(CU组)和88名无过敏史的健康者(对照组)的血清sFcεRIα和IgE水平、过敏原、皮肤划痕试验结果,比较两组间的差异,分析CU患者血清sFcεRIα水平与临床资料之间的相关性。结果 CU组的血清sFcεRIα和IgE水平均显著高于对照组(P值分别0.01、0.05)。CU患者的血清sFcεRIα与IgE水平呈负相关(r=-0.29,P=0.03)。过敏原与血清sFcεRIα和IgE水平均相关(r=0.624、0.332,P=3.74×10-8、0.043)。CU患者的血清sFcεRIα和IgE水平与皮肤瘙痒、风团数量和大小的评分总和,以及与病程、年龄和性别均不相关(P值均0.05)。高水平sFcεRIα(4.974μg/mL)患者皮肤划痕试验的阳性率达95.2%(20/21)。结论血清sFcεRIα和IgE水平与CU相关,CU患者的血清sFcεRIα与IgE水平呈负相关。
[Abstract]:Objective to determine the level of serum IgE and its soluble high affinity receptor alpha chain (sFc RI alpha) in patients with chronic urticaria (CU), and to understand the correlation between CU and IgE and their receptors. Methods 99 cases of CU patients (CU group) and 88 healthy persons without allergy history were determined by immunoblotting and immunoblotting by immunoblotting and immunoblotting respectively. The serum sFc epsilon RI alpha and IgE levels, the allergen and the skin scratch test results were compared between the two groups, and the correlation between the level of serum sFc e RI alpha and the clinical data in the serum of CU patients was analyzed. Results the serum sFc e RI alpha and IgE levels in the CU group were significantly higher than those of the control group (P 0.01,0.05). R=-0.29 (P=0.03). The serum sFc epsilon RI alpha of the allergen and the serum sFc RI alpha and IgE levels (r=0.624,0.332, P=3.74 x 10-8,0.043) and the sum of the scale and size of the skin and the mass and size of the skin were not related to the course of disease, age and sex (all 0.05). The positive rate of scar test was 95.2% (20/21). Conclusion serum levels of sFc e RI alpha and IgE are correlated with CU. CU sFc RI is a negative correlation with IgE level.
【作者单位】： 上海交通大学附属第一人民医院检验科;
【基金】：国家自然科学基金(81273276、810724480) 上海市科学技术委员会基金(11JC1410300)资助项目
【分类号】：R758.24
【共引文献】
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