脉冲射频联合臭氧介入综合治疗带状疱疹后神经痛的临床观察

发布时间：2018-05-24 18:19

本文选题：脉冲射频 + 背根神经节　；参考：《吉林大学》2017年硕士论文

【摘要】：目的:研究背根神经节脉冲射频术联合椎间孔注射臭氧及复合液的综合治疗带状疱疹后神经痛的有效性及安全性,为带状疱疹后神经痛的治疗提供一种疗效好、痛苦少的治疗方案。方法:选取胸、腹背部的带状疱疹后神经痛(PHN)患者62例,随机分成实验组(32例)和对照组(30例)。对照组:应用CT引导下背根神经节脉冲射频术联合椎间孔注射复合液治疗;实验组:应用CT引导下背根神经节脉冲射频术联合椎间孔注射复合液及臭氧治疗。应用简式McGill疼痛问卷表(short-form of McGill pain questionnaire,SF-MPQ)观察记录两组患者术前、术后不同时间段的疼痛评定指数(pain rating index,PRI)、视觉模拟评分(visual analogue score,VAS)、现时疼痛强度(present pain intensity,PPI)及SF-MPQ随时间变化情况,同时比较两组间的差异。结果:两组间性别、年龄及病程差异无统计学意义(P0.05),且两组间术前PRI、VAS、PPI及SF-MPQ差异也无统计学意义(P0.05)。两组患者在术后7天、1个月、3个月及12个月时SF-MPQ中各项指标的评分均下降,与术前比较差异有统计学意义(P0.05)。在组内比较中,两组术后7天、1个月、3个月的各评价指标之间比较有显著差异(P0.001),但术后3个月与12个月比较差异无统计学意义(P0.05)。组间比较中,实验组在术后各时间段的PRI、VAS、SF-MPQ以及术后7天、1个月的PPI的评分均下降明显高于对照组,差异有统计学意义(P0.05)。但实验组与对照组术后3个月、12个月的PPI评分无统计学差异。两组均未出现与本研究相关的不良反应及不良事件发生。结论:两种镇痛治疗方案均能有效缓解带状疱疹后神经痛患者的剧烈疼痛;CT引导下背根神经节脉冲射频术联合复合液+臭氧治疗更能快速而显著缓解带状疱疹后神经痛。
[Abstract]:Objective: to study the efficacy and safety of pulse radiofrequency of dorsal root ganglion (DRG) combined with intervertebral foramen injection of ozone and compound solution in the treatment of postherpetic neuralgia, and to provide a good curative effect for the treatment of postherpetic neuralgia. A less painful treatment. Methods: 62 patients with postherpetic neuralgia were randomly divided into experimental group (n = 32) and control group (n = 30). The control group was treated with CT-guided pulsed-radiofrequency of dorsal root ganglion (DRG) combined with intervertebral foramen injection of compound fluid, while the experimental group was treated with CT-guided RFA combined with intervertebral foramen injection of composite fluid and ozone therapy. Using short-form of McGill pain questionnaire SF-MPQs, the pain rating index and visual analogue scale (VAS) were observed and recorded in two groups of patients before and after operation. The visual analogue score (VAS) and the present pain intensity (PPI) and SF-MPQ (SF-MPQ) were measured over time. The differences between the two groups were also compared. Results: there was no significant difference in sex, age and course of disease between the two groups, and there was no significant difference in PPI and SF-MPQ between the two groups before operation. After 7 days, 1 month, 3 months and 12 months after operation, the scores of SF-MPQ in the two groups were significantly lower than those before operation (P 0.05). In the intra-group comparison, there was significant difference between the two groups on the 7th day, the 1st month and the 3rd month after operation (P 0.001), but there was no significant difference between the 3 months and 12 months after the operation (P 0.05). Compared with the control group, the PPI scores of the experimental group were significantly lower than those of the control group at each time after operation, and at 7 days after operation, the difference was statistically significant (P 0.05). However, there was no significant difference in PPI score between the experimental group and the control group at 3 months and 12 months after operation. There were no adverse reactions and adverse events related to this study in both groups. Conclusion: both of the two analgesic treatments can effectively relieve severe pain in patients with postherpetic neuralgia. CT-guided pulsed radiofrequency ablation of dorsal root ganglion combined with ozone combined with liquid ozone can relieve postherpes neuralgia more quickly and significantly.
【学位授予单位】：吉林大学
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：R752.12

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