云南地区170例太田痣患者发病特征及Q开关Nd:YAG1064nm激光疗效的回顾性研究

发布时间：2018-05-25 11:00

  本文选题：太田痣 + 调Q开关Nd　； 参考：《昆明医科大学》2017年硕士论文

【摘要】：[目的]:观察云南地区170例太田痣患者发病特征,回顾性调查Q开关Nd:YAG 1064nm激光治疗疗效和不良反应。[方法]:收集2011年1月至2014年1月在昆明医科大学第一附属医院皮肤科首诊并接受调Q开关Nd:YAG 1064nm激光治疗的云南地区太田痣患者170例,对其发病特点、激光疗效、影响疗效的相关因素、术后不良反应及复发等情况以问卷形式随访并进行临床分析。[结果]:受调查患者男女比例为1:3.72。29例患者出生即有(17.06%),儿童期发病多见(67.06%),部分青春期发病(27.06%)。双侧患病者占3.53%。男性发病高峰出现在婴儿期:0-1岁,女性发病的两个高峰分别是0-3岁、10-18岁。所有患者治疗1-6次,治疗4次时,患者和医生评价的总有效率分别为79.99%、80%;治疗6次时,患者和医生评价的总有效率分别为97.84%、97.85%;不同治疗次数疗效差异有统计学意义(P0.001)。治疗4次时,褐色皮损患者疗效优于蓝黑色皮损患者(P0.05) ; Tanino分型中Ⅰ、Ⅱ型患者疗效优于其他分型(P0.05);病程小于10年的患者疗效优于病程大于10年的患者(P0.05)。首次治疗年龄≤1岁者疗效优于1-10岁者,1-10岁者疗效优于10-20岁者,10-20岁者疗效优于20岁者,四者差异有显著性(P0.05);随访半年以上,术后不良反应的发生率为16.47%,三岛分型Ⅱ型更易发生色素沉着;随着治疗次数增加,色沉风险同时也增加。复发率为6.47%,发病年龄越早越容易复发。[结论]:就诊的云南地区太田痣患者的男女比例、发病年龄等发病临床特征与其他地区不尽相同,但趋势相似。使用调Q开关Nd:YAG1064nm激光治疗太田痣安全有效,术后不良反应及复发发生率低。患者治疗次数越多,痊愈率越高;褐色皮损及Tanino分型Ⅰ、Ⅱ型患者疗效更优;患者首次治疗年龄越小,病程越短,治疗相同次数所达到的总有效率越高,因此越早进行激光治疗,疗效越好。
[Abstract]:Objective: to observe the clinical characteristics of 170 patients with nevus of Ota in Yunnan, and to investigate retrospectively the curative effect and adverse reaction of Q-switch Nd:YAG 1064nm laser. Methods: a total of 170 patients with nevus of Ota in Yunnan were first diagnosed and treated with Q-switched Nd:YAG 1064nm laser from January 2011 to January 2014 in Department of Dermatology, first affiliated Hospital of Kunming Medical University. The related factors influencing the curative effect, postoperative adverse reaction and recurrence were followed up by questionnaire and clinical analysis. [results]: the ratio of male to female was 1: 3.72.29 cases. There were 17.06 cases at birth, 67.06% in childhood and 27.06% in part of puberty. Patients with bilateral disease accounted for 3.53%. The highest incidence occurred in males aged 0-1 years in infancy, and the two peaks in females were 0-3 years and 10-18 years old respectively. All the patients were treated 1-6 times and 4 times, the total effective rate of patients and doctors were 79.99 and 800.The total effective rates of patients and doctors were 97.84 and 97.855.There was significant difference in the curative effect of different treatment times (P 0.001). After 4 times of treatment, the curative effect of brown lesions was better than that of blue-black lesions (P0.05), the efficacy of type 鈪，

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