丹参酮联合米诺环素治疗中、重度痤疮35例临床观察

发布时间：2018-05-30 19:57

本文选题：丹参酮 + 米诺环素　；参考：《中国皮肤性病学杂志》2017年02期

【摘要】：目的探讨丹参酮胶囊联合米诺环素治疗中、重度痤疮的临床疗效及安全性。方法将入选的92例中、重度痤疮患者随机分为三组,治疗组(35例)予丹参酮胶囊联合米诺环素口服治疗,对照1组(28例)予口服丹参酮胶囊治疗,对照2组(29例)予米诺环素胶囊口服治疗,三组患者均同时外用夫西地酸乳膏,疗程8周。结果治疗8周后,治疗组有效率91.43%,明显高于对照1组有效率(67.86%)和对照2组有效率(72.41%),差异有统计学意义(P0.05),而对照1组和对照2组有效率的差异无统计学意义(P0.05)。随访:对照2组复发率(33.33%,3例/9例)略高于治疗组(20.00%,3例/15例)和对照1组(22.22%,2例/9例),但差异无统计学意义(P0.05)。结论丹参酮胶囊联合米诺环素治疗中、重度痤疮疗效和安全性均较好。
[Abstract]:Objective to investigate the clinical efficacy and safety of Danshentong Capsules combined with minocycline in the treatment of severe acne. Methods 92 patients with severe acne were randomly divided into three groups. The treatment group (35 cases) was treated with Danshentong Capsules combined with minocycline, and 1 groups (28 cases) were given oral administration of Danshentong Capsules, and 2 groups (29 cases) were given Mino. The three groups were treated with Fusidic Acid Cream for 8 weeks at the same time. After 8 weeks of treatment, the effective rate of the treatment group was 91.43%, which was significantly higher than that of the control group (67.86%) and the control 2 groups (72.41%). The difference was statistically significant (P0.05), but there was no significant difference between the control 1 groups and the control 2 groups (P0.05). Follow up: the recurrence rate of 2 groups (33.33%, 3 cases /9) was slightly higher than that of the treatment group (20%, 3 cases /15) and the control 1 groups (22.22%, 2 cases /9), but the difference was not statistically significant (P0.05). Conclusion the efficacy and safety of severe acne with Danshentong Capsules combined with minocycline were better.
【作者单位】：大连市友谊医院;大连医科大学附属第二医院;
【分类号】：R758.733

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