中西医结合治疗泛发性脓疱型银屑病182例回顾性分析

发布时间：2018-05-31 17:02

本文选题：泛发性脓疱型银屑病 + 中西医结合治疗　；参考：《辽宁中医药大学》2017年硕士论文

【摘要】：目的:通过对沈阳市第七人民医院皮肤科近2年来泛发性脓疱型银屑病患者病历进行回顾性分析,总结泛发性脓疱型银屑病的一般发病情况及治疗经验,加强对本病的认识,为今后预防和治疗提供参考依据。材料与方法:回顾性调查2014年2月-2016年11月于沈阳市第七人民医院皮肤科住院治疗的泛发性脓疱型银屑病患者的住院病历,对其性别、年龄、病程、发病季节、诱因、疾病史、家族史、生活习惯、皮肤表现、特殊受累、伴随症状、实验室检查、既往治疗情况、住院天数、住院期间用药情况、疗效评价等项目进行登记,应用统计学方法得出相关结论。结果:1.一般情况:共182例患者,男性95例,女性87例,男女比为1.09:1。平均年龄46.55±17.92岁。平均发病年龄44.04±18.65岁。病程2天-40年不等。平均住院天数24.24±14.06天。发病多于冬春季节。2.诱因:122例本次发病无明显诱因,感染诱发19例,药物诱发37例,其他原因诱发4例。3.疾病史:29例患者否认疾病史。其余病例均有1种或多种疾病。4.家族遗传史:有寻常型银屑病家族史5例;5.实验室检查:白细胞升高82例;中性粒细胞升高90例;血小板计数升高22例;尿常规异常43例;肝功异常28例;总胆红素升高18例;间接胆红素升高14例;肾功异常16例;尿酸升高20例;血钙下降29例;总蛋白、白蛋白降低98例;血脂异常57例;32例行疱液细菌培养,14例结果为阴性;C-反应蛋白升高57例;超敏C反应蛋白升高26例;总Ig E阳性67例;T细胞亚群比例紊乱24例。6.治疗结果:治愈106例,显效67例,有效1例,无效8例,总有效率为95.05%。结论:1.泛发性脓疱型银屑病病程长、易复发,可发生于任何年龄阶段,男女均可患病;好发于冬春季节。2.泛发性脓疱型银屑病病因不明,诱发因素多为感染和药物使用不当。3.中西医结合治疗泛发性脓疱型银屑病疗效显著,总有效率达95.05%。
[Abstract]:Objective: to analyze retrospectively the medical records of patients with generalized pustular psoriasis in the Department of Dermatology of the Seventh people's Hospital of Shenyang in recent two years, and to summarize the general incidence and treatment experience of generalized pustular psoriasis, so as to strengthen the understanding of the disease. To provide reference for prevention and treatment in the future. Materials and methods: the medical records of patients with generalized pustular psoriasis who were hospitalized in Department of Dermatology, Seventh people's Hospital of Shenyang from February 2014 to November 2016 were retrospectively investigated. Their sex, age, course of disease, onset season, inducement, history of disease were analyzed. Family history, living habits, skin manifestation, special involvement, accompanying symptoms, laboratory examination, past treatment, hospitalization days, drug use during hospitalization, curative effect evaluation and other items were registered, and the relevant conclusions were obtained by statistical method. The result is 1: 1. General: 182 patients, 95 males and 87 females, with a ratio of 1. 09: 1. The average age was 46.55 卤17.92 years old. The mean age of onset was 44.04 卤18.65 years old. The course of disease ranged from 2 days to 40 years. The average hospitalization days were 24.24 卤14.06 days. The incidence was more than that in winter and spring. There were 19 cases of infection, 37 cases of drug induction and 4 cases of other causes. History of disease: 29 patients denied the history of disease. The rest had one or more diseases. Family genetic history: 5 cases with psoriasis vulgaris. Laboratory examination showed that there were 82 cases of leukocytosis, 90 cases of neutrophils, 22 cases of platelet count, 43 cases of abnormal urine routine, 28 cases of abnormal liver function, 18 cases of total bilirubin, 14 cases of indirect bilirubin, 16 cases of abnormal renal function. Uric acid increased in 20 cases, serum calcium decreased in 29 cases, total protein and albumin decreased in 98 cases, dyslipidemia in 32 cases, vesicular fluid bacterial culture in 14 cases, negative increase of C-reactive protein in 57 cases, hypersensitive C-reactive protein in 26 cases, hypolipidemia in 32 cases, hypersensitive C-reactive protein in 26 cases. Total IgE was positive in 67 cases with disorder of T cell subsets in 24 cases. Results: 106 cases were cured, 67 cases were effective, 1 case was effective and 8 cases were ineffective. The total effective rate was 95.05. Conclusion 1. Generalized pustular psoriasis has a long course of disease and is easy to recur. It can occur at any age. The etiology of generalized pustular psoriasis is unknown, and the inducing factors are infection and improper use of drugs. The curative effect of integrated traditional Chinese and western medicine on generalized pustular psoriasis is remarkable, the total effective rate is 95.05.
【学位授予单位】：辽宁中医药大学
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：R758.63

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