复方克林霉素凝胶与克林霉素磷酸酯外用溶液治疗痤疮的临床观察与费用比较

发布时间：2018-06-01 16:42

本文选题：医院制剂 + 复方克林霉素凝胶　；参考：《中国药房》2015年15期

【摘要】：目的:比较复方克林霉素凝胶与克林霉素磷酸酯外用溶液治疗痤疮的临床疗效、安全性及费用。方法:将符合标准的151例痤疮患者随机分为观察组(77例)和对照组(74例)。对照组患者给予克林霉素磷酸酯外用溶液喷于患处,每日早晚各1次+异维A酸软胶囊10 mg,口服,每日2次。观察组患者给予复方克林霉素凝胶涂于患处,每日早晚各1次+异维A酸软胶囊,用法同对照组。两组患者疗程均为8周。观察两组患者的临床疗效、治疗费用、成本效果比及不良反应发生情况。结果:两组患者总有效率、不良反应发生率比较差异均无统计学意义(P0.05)。观察组患者治疗费用、成本效果比均显著低于对照组,差异均有统计学意义(P0.05)。结论:复方克林霉素凝胶与克林霉素磷酸酯外用溶液治疗痤疮的疗效与安全性相当,但在治疗费用方面复方克林霉素凝胶优于克林霉素磷酸酯外用溶液。
[Abstract]:Objective: to compare the efficacy, safety and cost of compound clindamycin gel and clindamycin phosphate solution in the treatment of acne. Methods: 151 patients with acne were randomly divided into observation group (n = 77) and control group (n = 74). The patients in the control group were given clindamycin phosphate solution for external use, 10 mg of isotinic acid soft capsules in the morning and evening, once a day, twice a day. The patients in the observation group were treated with compound clindamycin gel in the affected area and treated with isotinic acid soft capsules once a day. The course of treatment was 8 weeks. To observe the clinical effect, treatment cost, cost effectiveness ratio and adverse reaction of the two groups. Results: there was no significant difference in the total effective rate and the incidence of adverse reactions between the two groups (P 0.05). The treatment cost and cost effect ratio in the observation group were significantly lower than those in the control group (P 0.05). Conclusion: the efficacy and safety of compound clindamycin gel and clindamycin phosphate solution in the treatment of acne are similar, but the cost of compound clindamycin gel is better than that of clindamycin phosphate solution.
【作者单位】：复旦大学附属华山医院北院;复旦大学附属华山医院;
【分类号】：R758.733

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