汉族人3915例特应性皮炎患者临床特征分析

发布时间：2018-06-14 10:27

  本文选题：汉族 + 特应性皮炎　； 参考：《安徽医科大学》2011年硕士论文

【摘要】：研究背景特应性皮炎(atopic dermatitis, AD)是一种慢性、炎症性、反复发作性疾病,好发于婴儿和儿童。很多大规模的AD流行病学调查是基于西方国家人群,而有关亚洲人群的研究较少。本研究对中国汉族3915例AD患者的流行病学特点和临床特征进行回顾性分析。 目的研究中国汉族3915例特应性皮炎患者的流行病学特点和临床特征。 方法收集2008年1月至2010年3月来自全国多家合作医院的3915例AD患者,均符合Hanifin-Rajka诊断标准。采用统一的问卷调查对病人及家属进行临床流行病学调查,应用Epi info 6.0软件和SPSS10.0软件对资料进行统计学处理和分析,男性与女性组、发病年龄2岁(又称早年发病组)和发病年龄≥2岁组的临床特征方面的差异采用卡方检验。 结果3915例AD患者男女比为1.5:1(男2333例,女1582例),发病年龄中位数位为2月,84.6%的患者于出生后2年内发病,且早年发病组中男性较女性多。家族特应性病史阳性患者2778(71%)例,“单纯型”AD 2267(57.9%)例,“混合型”AD 1684(42.1%)例,早年发病组中家族史阳性发生率高,而哮喘、过敏性鼻炎的发病率在早年发病组低(p均0.001)。本研究显示,53.0%的患者病情存在季节差异性,其余47.0%的患者病情则无明显季节差异性;84%的患者病情为轻到中度,男性病情较女性重(p0.05)。Hanifin-Rajka诊断标准的次要体征在AD患者中较常见的为干皮症(78%)、出汗时瘙痒(64.9%)和苍白脸/面部皮炎(58.4%);其他相关症状常见的为头皮皮炎(44.1%)、耳廓下裂隙(33.9%)和慢性头皮脱屑(22.6%)。苍白脸/面部皮炎、头皮皮炎、耳廓下裂隙、乳头湿疹、干皮症在早年发病组的发生率高,而眶周黑晕、白色糠疹、鱼鳞病/毛周角化/掌纹症、Dennie-Morgan眶下皱褶在发病年龄≥2岁组的发生率高(p均0.05)。另外,苍白脸/面部皮炎、皮肤感染倾向、乳头湿疹在男性中的发生率高于女性,而眶周黑晕、Dennie-Morgan眶下皱褶、鱼鳞病/毛周角化/掌纹症在女性中的发生率高(p均0.05)。 结论AD患者发病的流行病学特征、疾病严重程度及Hanifin-Rajka诊断标准中的部分次要体征在男性女性组及不同发病年龄组存在统计学差异,对中国汉族AD患者的诊断提供了线索和依据。
[Abstract]:Background atopic dermatitis (ADD) is a chronic, inflammatory and recurrent disease that occurs in infants and children. Many large-scale AD epidemiological surveys are based on Western populations, while less research has been done on Asian populations. The epidemiological and clinical features of 3915 AD patients in Chinese Han nationality were retrospectively analyzed. Objective to study the epidemiological and clinical characteristics of 3915 patients with atopic dermatitis in Chinese Han nationality. Methods from January 2008 to March 2010, 3915 AD patients from several cooperative hospitals in China were collected, all of whom were in accordance with the diagnostic criteria of Hanifin-Rajka. A unified questionnaire survey was used to investigate the clinical epidemiology of patients and their families. The data were statistically analyzed by Epi info 6.0 software and SPSS 10.0 software. Chi-square test was used for the difference of clinical characteristics between the onset age of 2 years old (also called early onset group) and the age of onset 鈮，

本文编号：2017073