米诺环素联合烟酰胺治疗121例大疱性类天疱疮

发布时间：2018-06-17 01:28

本文选题：大疱性类天疱疮 + 米诺环素　；参考：《临床皮肤科杂志》2014年11期

【摘要】：目的:了解米诺环素联合烟酰胺治疗大疱性类天疱疮的疗效。方法:121例大疱性类天疱疮患者初诊时给予米诺环素200mg/d;烟酰胺600-1500mg/d,服用2周。2周后复查,根据病情或继续口服米诺环素及烟酰胺;或米诺环素及烟酰胺加服少量泼尼松;或停服米诺环素及烟酰胺,改为单独服用泼尼松或用其他方法治疗,总共随访观察24周。结果:使用米诺环素联合烟酰胺治疗2周后达到完全控制40例(33.1%),基本控制48例(39.7%),无效33例(27.3%)。有效者合计88例(72.7%),最终完成24周米诺环素联合烟酰胺治疗的有29例(24.0%)。严重程度与2周后疗效,经Spearman相关分析,r=0.264,P=0.003,有显著相关性。结论:轻中度的大疱性类天疱疮患者,可以考虑首选米诺环素联合烟酰胺治疗。
[Abstract]:Objective: to investigate the efficacy of minocycline combined with nicotinamide in the treatment of bullous pemphigoid. Methods 121 patients with bullous pemphigoid were treated with minocycline 200 mg / d, nicotinamide 600-1500 mg / d for 2 weeks, followed up with minocycline and niacinamide according to their condition, or minocycline and nicotinamide plus a small amount of prednisone. Instead of minocycline and nicotinamide, prednisone alone or other treatment were followed up for a total of 24 weeks. Results: after 2 weeks of treatment with minocycline combined with nicotinamide, 40 cases (33.1%) were completely controlled, 48 cases (39.7%) were basically controlled, and 33 cases were ineffective. In total, 88 cases were effective and 29 cases were treated with minocycline combined with nicotinamide for 24 weeks. There was a significant correlation between the severity and the curative effect after 2 weeks by Spearman correlation analysis. Conclusion: milocycline combined with nicotinamide is the first choice for patients with bullous pemphigoid.
【作者单位】：北京大学第一医院皮肤性病科;郑州人民医院皮肤科;山东省皮肤病医院;
【基金】：国家自然科学基金重点项目(81130030);国家自然科学基金青年科学基金项目(81000694)
【分类号】：R758.66

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