Sox2、Pten、Stat3、Vegf在皮肤恶性黑色素瘤中表达的相关性研究

发布时间：2018-06-18 09:18

本文选题：皮肤恶性黑色素瘤 + Sox　；参考：《南京医科大学学报(自然科学版)》2017年11期

【摘要】：目的:探索SOX区域Y相关高迁移率族蛋白基因2(sry-related high-mobility box-2,Sox2)、人第10号染色体缺失的磷酸酶及张力蛋白同源基因(phosphatase and tensin homolog deleted on chromosome ten,Pten)、信号转导子与转录激活子3(signal transducers and activators of transcription,Stat3)、血管内皮细胞生长因子(vascular endothelial growth factor,Vegf)基因在皮肤恶性黑色素瘤(cutaneous malignant melanoma,CMM)中表达的联系。方法:采用免疫组织化学染色方法检测27例CMM蜡块中Sox2、Pten、Stat3和Vegf的表达。SPSS17.0软件处理实验数据,采用Spearman相关分析。结果 :在CMM中,Sox2、Stat3和Vegf的表达两两之间呈正相关;Sox2、Pten、Stat3的表达两两之间呈正相关;Pten与Vegf之间的表达无相关性。结论:在CMM的发生及演变中,Sox2、Stat3和Vegf之间或Pten、Sox2、Stat3之间可能存在单向信号调控或环状调控通路,可能在CMM的发生中存在作用。
[Abstract]:Objective: to explore the high mobility group protein gene 2(sry-related high-mobility box-2n Sox2 associated with Sox region, phosphatase and tensin homolog deleted on chromosome tenon, signal transduction and transcription activator 3(signal transducers and activators of transcriptionStat3, homologous gene of phosphatase and tension protein homologous to human chromosome 10. Expression of vascular endothelial growth factor-Vegfin gene in malignant melanoma of skin (CML). Methods: the expression of Sox2PtennStat3 and Vegf in 27 cases of CMM wax were detected by immunohistochemical staining. SPSS 17.0 software was used to process the experimental data. Spearman correlation analysis was used. Results: there was a positive correlation between the expression of Sox2nStat3 and Vegf in CMM. There was no correlation between the expression of Pten and Vegf. Conclusion: there may be unidirectional signal regulation or annular regulation pathway between Sox2NStat3 and Vegf or between Ptenn Sox2Stat3 and CMM, which may play an important role in the pathogenesis of CMM.
【作者单位】：南京医科大学第一附属医院整形烧伤科;
【基金】：国家自然科学基金(81472081)
【分类号】：R739.5

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