p16蛋白和PCNA在鳞状细胞癌组织中的表达及其与临床病理特征的关系

发布时间：2018-06-26 17:14

  本文选题：鳞状细胞癌 + p　； 参考：《中国皮肤性病学杂志》2017年09期

【摘要】：目的探讨p16蛋白和增殖细胞核抗原(PCNA)在鳞状细胞癌组织中的表达及其与临床病理特征的关系。方法利用免疫组织化学法(IHC)检测50例鳞状细胞癌患者的癌组织、癌旁组织和30例健康人群的正常组织中p16蛋白和PCNA的表达情况,并分析p16蛋白和PCNA与鳞状细胞癌临床病理特征的关系。结果鳞状细胞癌组织中p16蛋白阳性表达率显著低于癌旁组织和正常组织(P0.01),鳞状细胞癌组织中PCNA指数显著高于癌旁组织和正常组织(P0.01);p16蛋白阳性表达率随着癌组织浸润深度增加而降低(P0.01),PCNA指数随着癌组织浸润深度增加而增大(P0.01);PTNMⅠ~Ⅱ期p16蛋白阳性表达率显著高于PTNMⅢ~Ⅳ期(P0.01),PTNMⅠ~Ⅱ期PCNA指数显著低于PTNMⅢ~Ⅳ期(P0.01);p16阳性表达的鳞状细胞癌组织中PCNA指数为30.67±9.82,显著低于p16阴性表达的鳞状细胞癌组织中的51.96±12.43(P0.01)。结论在鳞状细胞癌组织中p16蛋白缺失,而PCNA大量表达,且p16蛋白和PCNA表达与鳞状细胞癌的病理分期和浸润深度密切相关,提示p16蛋白和PCNA可作为评价鳞状细胞癌病变程度的重要指标,对指导治疗鳞状细胞癌有重大意义。
[Abstract]:Objective to investigate the expression of p16 protein and proliferating cell nuclear antigen (PCNA) in squamous cell carcinoma (SCC) and their relationship with clinicopathological features. Methods Immunohistochemical assay (IHC) was used to detect the expression of p16 protein and PCNA in cancer tissues of 50 patients with squamous cell carcinoma, adjacent tissues and 30 healthy controls. The relationship between p16 protein and PCNA and clinicopathological features of squamous cell carcinoma was analyzed. Results the positive expression rate of p16 protein in squamous cell carcinoma tissues was significantly lower than that in adjacent tissues and normal tissues (P0.01). The PCNA index in squamous cell carcinoma tissues was significantly higher than that in paracancerous tissues and normal tissues (P0.01). The positive rate of p16 protein expression in PTNM 鈪，

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