T细胞亚群及其细胞因子在寻常型银屑病中的作用机制研究

发布时间：2018-06-26 18:04

本文选题：T淋巴细胞亚群 + 银屑病　；参考：《重庆医学》2017年26期

【摘要】：目的探讨T细胞亚群及其细胞因子在寻常型银屑病发病中的作用机制。方法连续性收集2014年1月至2016年2月该院门诊诊治的寻常型银屑病患者50例作为研究组,同期收集50例至该院体检的健康成人50例作为对照组。观察两组患者外周血中Th17细胞、Treg细胞,白细胞介素(IL)-2、IL-10、转化生长因子(TGF-β)、IL-17和IL-23。结果与对照组比较,研究组患者Th17细胞显著增加[(0.28±0.08)%vs.(0.88±0.14)%,P=0.000];Treg细胞显著减少[(6.27±2.47)%vs.(3.85±1.27)%,P=0.000]。与对照组比较,研究组患者IL-2、IL-17、IL-23水平显著升高,IL-10、TGF-β显著降低(P0.05)。银屑病患者PASI评分为(18.58±6.49)分。Pearson线性相关性分析显示PASI与Th17、IL-2和IL17显著正相关,与Treg和TGF-β显著负相关(P0.05)。多元线性回归分析显示Th17、Treg和IL-17是影响银屑病患者PASI的免疫因素(P0.05)。结论寻常型银屑病患者Th17、Treg细胞及相关细胞因子水平平衡失调,且与病情严重度相关。
[Abstract]:Objective to investigate the role of T cell subsets and cytokines in the pathogenesis of psoriasis vulgaris. Methods from January 2014 to February 2016, 50 patients with psoriasis vulgaris were selected as study group and 50 healthy adults as control group. Th17 cells, IL-10, TGF- 尾, IL-17 and IL-23 in peripheral blood were observed. Results compared with the control group, Th17 cells in the study group increased significantly [(0.28 卤0.08) vs. (0.88 卤0.14) vs 0.000] the number of Treg cells decreased significantly [(6.27 卤2.47) vs. (3.85 卤1.27) vs 0.000]. Compared with the control group, the level of IL-2, IL-17 and IL-23 in the study group was significantly higher than that in the control group (P0.05). The PASI score of psoriasis patients was (18.58 卤6.49). Pearson linear correlation analysis showed that PASI was positively correlated with Th17, IL-2 and IL-17, and negatively correlated with Treg and TGF- 尾 (P0.05). Multiple linear regression analysis showed that Th17 Treg and IL-17 were the immune factors affecting PASI in psoriatic patients (P0.05). Conclusion Th17 Treg cells and related cytokines in patients with psoriasis vulgaris are unbalanced and correlated with the severity of the disease.
【作者单位】：南通大学附属医院皮肤性病科;
【基金】：南通市科技项目(MS22015128)
【分类号】：R758.63

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