外用花椒油治疗慢性局限性湿疹的疗效观察

发布时间：2018-06-29 20:57

本文选题：慢性局限性湿疹 + 花椒油　；参考：《湖北中医药大学》2017年硕士论文

【摘要】：目的探讨外用花椒油治疗慢性局限性湿疹的疗效。方法1.收集符合入选标准的57例慢性局限性湿疹患者,按照就诊顺序随机分为实验组和对照组。实验组予以花椒油外搽,2次/天,对照组予以地奈德乳膏外用,2次/天,治疗周期为2周。2.在治疗前及治疗第2周末评估记录各观察指标包括瘙痒评分(VAS)、皮损评分(EASI),并记录其不良反应,由同一人为患者照相,进行图片采集。3.所得数据均采用双侧检验,以秩和检验比较组内治疗前后及组间有关计量资料,卡方检验检验比较计数资料,显著性检验水平为0.05,P≤0.05为差异有统计学意义,P≥0.05为差异无统计学意义,比较疗效。结果1.共55例患者完成了临床研究。实验组治愈、显效、好转、无效人数分别为1人、3人、17人、7人,总有效率75%。对照组治愈、显效、好转、无效人数分别为2人、3人、16人、6人,总有效率77.8%。两组之间差异无统计学差异P0.05。2.实验组、对照组中瘙痒评分、皮损评分、症状总积分各评分与初诊比较显著降低,P0.001;实验组和对照组症状积分相比较,P=0.6920.05,说明两组之间疗效没有统计学差异。3.实验组瘙痒和皮损评分分别从治疗前的2.38±0.56、12.27±5.73降为0.79±0.71、7.77±4.08(P0.001);对照组瘙痒和皮损评分分别从治疗前的2.41±0.636、11.72±3.24降为0.76±0.74、7.19±3.48(P0.001);且两组在治疗后评分较治疗前显著降低(P0.001)。4.实验组症状总积分在治疗前为14.64±5.95,治疗后降为8.55±4.23,显著降低;对照组症状总积分在治疗前为14.13±3.61,治疗后降为7.94±4.00,也显著降低,且两组之间症状总积分无统计学差异(P0.05)。结论外用花椒油治疗慢性局限性湿疹可以有效缓解患者的瘙痒不适、减轻皮损症状,同时安全性高,有较好的推广价值。
[Abstract]:Objective to investigate the effect of zanthoxylum oil on chronic localized eczema. (1.) to collect 57 patients with chronic localized eczema, which were randomly divided into experimental and control groups according to the order of admission. The experimental group was treated with zanthoxylum oil outside, 2 times / day, and the control group was treated with Desonide cream for 2 times / day, and the treatment cycle was 2 weeks.2.. Before and after second weeks of treatment, the observation indexes including pruritus score (VAS), skin lesion score (EASI), and their adverse reactions were recorded by the same person, and the data collected by.3. were both bilateral test, and the relative measurement data were compared before and after treatment in the group. The number of data, the level of significant test was 0.05, P < 0.05 was statistically significant, P > 0.05 was no statistical significance, and the effect was compared. Results 1. of the 55 patients completed clinical study. The experimental group was cured, effective, and improved, the number of invalid was 1, 3, 17, 7, total effective, 75%. control group cured, effective, improved, invalid. 2 people, 3 people, 16 people, 6 people, the total effective 77.8%. two groups had no statistical difference between the P0.05.2. experimental group, the control group in the pruritus score, the skin lesion score, the total score of the symptom and the initial diagnosis were significantly lower, P0.001; the experimental group and the control group were compared with the symptom score, P=0.6920.05, indicating that there was no statistical difference between the two groups. The pruritus and skin lesions of the.3. group decreased from 2.38 + 0.56,12.27 + 5.73 before treatment to 0.79 + 0.71,7.77 + 4.08 (P0.001), and the pruritus and skin lesions of the control group decreased from 2.41 + 0.636,11.72 + 3.24 before treatment to 0.76 + 0.74,7.19 + 3.48 (P0.001), and the scores of the two groups were significantly lower than those before treatment (P0.001).4. experimental group. The total score was 14.64 + 5.95 before treatment and decreased to 8.55 + 4.23 after treatment. The total score of symptoms in the control group was 14.13 + 3.61 before treatment and 7.94 + 4 after treatment. There was no significant difference in the total symptom score between the two groups (P0.05). Conclusion external use of pepper oil for chronic localized eczema could effectively relieve the patients. Itching is not good, relieve the symptoms of skin lesions, and at the same time, it has high safety, and has a good promotional value.
【学位授予单位】：湖北中医药大学
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：R758.23

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