非甾体抗炎药致重症药疹文献汇总分析

发布时间：2018-07-04 15:35

本文选题：非甾体抗炎药 + 重症药疹　；参考：《中国医院药学杂志》2017年21期

【摘要】：目的:以临床实例出发探讨非甾体抗炎药致重症药疹的特点和关联性,为临床用药安全提供参考。方法:通过检索1970-2017年国内外期刊数据库公开报道的非甾体抗炎药致重症药疹的病例,提取文献中患者年龄、性别、致ADR药物、重症药疹类型等信息进行统计和分析。结果:非甾体抗炎药致重症药疹文献49篇,共计病例49例。其中单一用药致重症药疹病例有27例,联合用药22例;49例非甾体抗炎药致重症药疹中发生率最高为对乙酰氨基酚,其次为吡罗昔康、布洛芬、依托考昔;非甾体抗炎药致重症药疹平均潜伏期为(7.88±10.42)d,其中致药物超敏反应综合征潜伏期最长,可长达(36.50±14.20)d;大部分患者停药后好转,1例因中毒性表皮坏死松解征死亡。结论:非甾体抗炎药致重症药疹具有潜在的危险性,临床应用时应提高警惕,以减少重症药疹给患者带来的危害。
[Abstract]:Objective: to explore the characteristics and correlation of severe drug eruption caused by NSAIDs in order to provide reference for clinical safety. Methods: the data of patients with severe drug eruption caused by NSAIDs from 1970 to 2017 were retrieved and analyzed. The data of age, sex, ADR drugs and types of severe drug eruption were extracted from the literature. Results: there were 49 articles about severe drug eruption caused by NSAIDs, including 49 cases. There were 27 cases of severe drug rash caused by single drug use, and 22 cases (49 cases) of severe drug rash caused by non-steroidal anti-inflammatory drugs. The highest incidence rate was acetaminophen, followed by Piroxicam, ibuprofen, etoxib. The average latency of severe drug rash induced by NSAIDs was (7.88 卤10.42) days, and the latency of drug-induced hypersensitivity syndrome was the longest (36.50 卤14.20) days. Conclusion: Non-steroidal anti-inflammatory drugs have potential danger in severe drug rash, so we should be vigilant in clinical application in order to reduce the harm caused by severe drug eruption.
【作者单位】：北京大学人民医院药剂科;中国药科大学基础医学与临床药学学院;
【分类号】：R758.25

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