外毛根鞘癌7例临床病理分析

发布时间：2018-07-05 17:37

本文选题：外毛根鞘癌 + 临床病理学　；参考：《临床与实验病理学杂志》2017年10期

【摘要】：目的探讨外毛根鞘癌(trichilemmal carcinoma,TC)的临床病理学特征、诊断及鉴别诊断。方法回顾性分析7例TC患者的临床资料、组织学形态及免疫表型,并复习相关文献。结果 7例患者年龄22~63岁,平均40.5岁,其中男性4例,女性3例。皮损均发生于头面部,表现为孤立的外生性团块。镜检:肿瘤组织呈分叶状、索条状,主要由不典型的透明细胞组成,以伴有外毛根鞘角化的上皮细胞增生为特征。免疫表型:7例PAS染色,透明细胞均(+),CK5和CK14均(+),CEA、S-100和HMB-45均(-)。7例患者均行手术切除术。6例患者随访1~5年,无复发及转移。结论TC是低度恶性的附属器肿瘤,具有局部侵袭性、基本不复发、转移的特点。诊断依据分叶状结构及外毛根鞘分化特点。手术切除,预后好。需与外毛根鞘瘤及其他透明细胞肿瘤鉴别。
[Abstract]:Objective to investigate the clinicopathological features, diagnosis and differential diagnosis of trichilemmal carcinoma. Methods the clinical data, histological morphology and immunophenotype of 7 patients with TC were analyzed retrospectively. Results the age of 7 patients was 22 ~ 63 years (mean 40.5 years), including 4 males and 3 females. Skin lesions occur on the head and face, showing an isolated ectogenic mass. Microscopic examination: tumor tissue is lobulated, cord-like, mainly composed of atypical transparent cells, characterized by the proliferation of epithelial cells with keratosis of outer hair root sheath. Immunophenotype: pas staining was performed in 7 cases, and clear cells were (1) CK5 and CK14 () CEAS-100 and HMB-45 (-). 6 cases were followed up for 1 ~ 5 years without recurrence or metastasis. Conclusion TC is a low grade malignant adnexal tumor with local invasiveness, no recurrence and metastasis. The diagnosis was based on lobular structure and differentiation of outer hair root sheath. Surgical resection has a good prognosis. It should be distinguished from outer hair root sheath tumor and other clear cell tumors.
【作者单位】：西南医科大学附属医院皮肤科;西南医科大学附属医院病理科;
【基金】：西南医科大学附属医院院内基金(2015-QS-035)
【分类号】：R739.5

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