银屑病与肾脏疾病的相关性研究

发布时间：2018-07-07 21:25

本文选题：尿微量白蛋白 + 银屑病　；参考：《临床皮肤科杂志》2014年07期

【摘要】：目的:研究银屑病患者肾脏功能的变化情况。方法:53例银屑病患者,其中男38例,女15例,平均年龄(46±12)岁,以年龄和性别相匹配的健康者53例个体为对照组。用银屑病皮损面积和严重程度指数(PASI)评估银屑病的严重程度。所有患者及对照组均行尿液分析包括尿常规及尿沉渣镜检、24 h尿蛋白定量及尿微量白蛋白。其中尿微量白蛋白30mg/L认为病理性白蛋白尿,对尿液检查异常的银屑病患者进行肾活检。结果:①银屑病患者和对照组的尿常规分析及镜检差异均无统计学意义(P0.05);两组间的平均24 h蛋白尿、尿微量白蛋白差异均无统计学意义(P0.05);但与对照组相比,银屑病患者病理性白蛋白尿的发生率显著增加(分别为24%和2%,P0.01)。②银屑病患者的PASI分数与24 h白蛋白尿显著相关(r=0.458,P0.01)。其中9例银屑病患者有肾功能异常,4例进行了肾活检,证实2例为肾小球肾炎,且均为系膜增殖性肾小球肾炎。结论:银屑病患者中肾脏异常并不常见,而病理性白蛋白尿发生率显著增加,且与银屑病的严重程度相关,提示银屑病患者可能存在早期肾功能损害。
[Abstract]:Objective: to study the changes of renal function in patients with psoriasis. Methods 53 patients with psoriasis, including 38 males and 15 females, with an average age of (46 卤12) years, were enrolled in the study. 53 healthy controls were matched by age and sex. Psoriasis severity was evaluated by psoriasis area and severity index (PASI). All the patients and the control group underwent urine analysis including urine routine examination and microscopic examination of urine sediment for 24 h urinary protein quantification and urinary microalbumin. Among them, 30 mg / L of urinary microalbuminuria was regarded as pathological albuminuria, and renal biopsy was performed in psoriatic patients with abnormal urine examination. Results there was no significant difference in urine routine analysis and microscopic examination between psoriasis patients and control group (P0.05), but there was no significant difference in 24 h proteinuria and urinary microalbuminuria between the two groups (P0.05), but compared with the control group, there was no significant difference in urinary microalbuminuria between the two groups (P0.05). The incidence of pathological albuminuria in psoriatic patients was significantly increased (24% and 2% P0.01 respectively) .2 the PASI score of psoriasis patients was significantly correlated with 24 h albuminuria (r = 0.458p 0.01). Renal biopsy was performed in 4 of 9 psoriatic patients with abnormal renal function. 2 cases were confirmed as glomerulonephritis and all cases were Mesangial proliferative glomerulonephritis. Conclusion: renal abnormalities are not common in psoriatic patients, but the incidence of pathological albuminuria is significantly increased, which is related to the severity of psoriasis, suggesting that early renal dysfunction may exist in patients with psoriasis.
【作者单位】：南京医科大学第一附属医院皮肤性病科;南京医科大学第一附属医院心脏科;
【基金】：江苏省六大人才高峰资助项目(2013-WSN-031)
【分类号】：R758.63

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