中国南北方特应性皮炎患者临床特征患病率的差异

发布时间：2018-07-08 12:15

本文选题：特应性皮炎 + 临床特征　；参考：《安徽医科大学》2011年硕士论文

【摘要】：背景特应性皮炎(Atopic dermatitis,AD)是一种慢性复发性、瘙痒性、炎症性皮肤疾病,与遗传因素、环境因素、免疫因素等有关,常自婴幼儿期起病,病情易反复,部分患者可持续至成年期。近三十年,全世界范围内患病率呈逐年上升趋势,尤其以西方工业发达国家为甚,又因特应性皮炎主要发生于儿童、青少年,特别是婴幼儿,病情易反复、瘙痒难当,对处于生理和心理正处发育阶段的低龄患者造成的影响不可估量。因此,对特应性皮炎的病因学研究已成了近二十年的研究热点,并在遗传基因学、免疫学、环境因素及过敏原等方面取得了重大成果。但无论国内国外,关于地域性差异对特应性皮炎发病情况的影响仅局限于部分临床特征或某一因素,无系统性统计。AD是一种复杂疾病,呈非孟德尔遗传模式,具有较强的种族差异和遗传异质性,为探讨特应性皮炎在不同地域发病的情况,本研究应用课题组AD易感基因的GWA研究初步结果(未发表),分析AD在遗传基因学基础下在不同地域的发病情况的差异,进一步为AD的临床特征发生率与不同地域的不同因素的关系的研究奠定基础。目的探讨特应性皮炎的临床特征在中国南北方患者发生情况的差异。方法采用回顾性研究并用调查表的形式收集患者的资料,并分析各临床特征在南北方患者中发生概率的差异性。结果1.个人异位史患者发生情况:在南方患者中(48.2%)高于北方(26.4%),具有统计学差异(P0.05),家族异位史发生情况:在北方患者(78.2%)中高于南方(66.9%)具统计学意义(P0.05); 2.患病季节:南北方AD患者在发病季节上总体具有差异性(P0.05),夏季北方的发病率显著高于南方的发病率(P0.05)、秋季南方的发病率显著高于北方(P0.05); 3.疾病严重程度:轻度患者在北方患者中的发生情况比南方患者搞(P0.05)、而南方患者中度的患者发生情况比北方患者中高(P0.05); 4.次要症状和其他症状:次要体征中有十五项南北方有显著差异,其他症状中五项南北方有差异(P0.05),已被列入诊断标准的:干皮病、乳头湿疹、面部皮炎、非特异性手足皮炎的发生率在北方显著高于南方(P0.05),而毛周隆起则在南方的发生率更高些(P0.05)。结论研究表明特应性皮炎在中国南北方的发病情况具有显著地域性差异。
[Abstract]:Background Atopic dermatitis AD is a chronic recurrent, pruritus, inflammatory skin disease related to genetic factors, environmental factors, immune factors and so on. In the past three decades, the prevalence rate has been increasing year by year in the world, especially in the developed countries of western industry, and the incidence of atopic dermatitis mainly occurs in children, adolescents, especially infants, the disease is easy to repeat and itching is difficult. The effect on young patients in physiological and psychological stages of development is incalculable. Therefore, the etiology of atopic dermatitis has become a hot topic in recent 20 years, and great achievements have been made in genetic genetics, immunology, environmental factors and allergens. However, whether at home or abroad, the influence of regional differences on the incidence of atopic dermatitis is limited to some clinical features or a certain factor. There is no systematic statistical analysis. AD is a complex disease, which is a non-Mendelian genetic model. In order to investigate the incidence of atopic dermatitis in different regions, In this study, the preliminary results of the GWA study of AD susceptibility genes (not published) were used to analyze the differences in the incidence of AD in different regions on the basis of genetic genetics. Further more, it will lay a foundation for the study of the relationship between the incidence of AD clinical characteristics and different factors in different regions. Objective to investigate the clinical characteristics of atopic dermatitis in patients in the north and south of China. Methods the data of patients were collected by retrospective study and questionnaire, and the differences of occurrence probability among patients in North and South were analyzed. Result 1. The incidence of individual ectopic history in the patients in the south (48.2%) was higher than that in the north (26.4%), and there was statistical difference (P0.05). The incidence of family ectopic history in the northern patients (78.2%) was higher than that in the south (66.9%) (P0.05); 2. Disease season: the incidence of AD patients in the south and north had the overall difference in the onset season (P0.05), the incidence in summer was significantly higher than that in the south (P0.05), the incidence in autumn was significantly higher than that in the north (P0.05); 3. The severity of disease: the incidence of mild patients in the northern patients was higher than that in the southern patients (P0.05), while the incidence of moderate patients in the southern patients was higher than that in the northern patients (P0.05); 4. Secondary symptoms and other symptoms: fifteen Xiang Nan and five other symptoms had significant differences in the north and south (P0.05), which had been included in the diagnostic criteria: dry dermatosis, nipple eczema, facial dermatitis, The incidence of nonspecific hand and foot dermatitis in the north was significantly higher than that in the south (P0.05), while the incidence of the hair circumference was higher in the south (P0.05). Conclusion the study showed that the incidence of atopic dermatitis in the north and south of China was significantly different in different regions.
【学位授予单位】：安徽医科大学
【学位级别】：硕士
【学位授予年份】：2011
【分类号】：R758.23

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