应用光学相干层析术研究光动力治疗鲜红斑痣前后皮肤结构和光学参数的变化

发布时间：2018-07-08 12:45

本文选题：医用光学 + 光学相干层析成像　；参考：《中国激光》2015年06期

【摘要】：研究鲜红斑痣(PWS)组织结构和光学特性在光动力治疗(PDT)前后的变化有利于客观评价疗效及指导后续治疗。通过分析光学相干层析术(OCT)采集的光学相干信号在PWS不同组织结构中的特征,得到治疗前后PWS的表皮层厚度以及扩张血管的管径和深度;基于扩展的Huygens-Fresnel原理与最小二乘法对PWS的OCT纵向信号进行拟合,获取治疗前后组织的散射特性参数。分析上述参数在28例PWS患者PDT治疗前后的变化。治疗后表皮层厚度及各层散射系数无明显改变(p0.05),扩张血管的平均管径减小,扩张血管的平均深度增加(p0.05)。本研究实现了OCT对PWS结构参数和光学参数的在体无创测量。研究结果表明将PWS各参数在PDT治疗前后的变化作为评价治疗效果和调整治疗方案的参考依据具有一定的可行性。
[Abstract]:Studying the changes of tissue structure and optical properties of PWS before and after photodynamic therapy (PDT) is helpful for objective evaluation of curative effect and guidance for follow-up treatment. By analyzing the characteristics of optical coherent signals collected by optical coherence tomography (Oct) in different tissue structures of PWS, the thickness of the epidermis and the diameter and depth of dilated vessels were obtained before and after treatment. Based on the extended Huygens-Fresnel principle and the least square method, the longitudinal signals of Oct of PWS were fitted to obtain the scattering characteristic parameters of tissues before and after treatment. The changes of above parameters before and after PDT in 28 PWS patients were analyzed. After treatment, the thickness of epidermis and scattering coefficient of each layer did not change significantly (p0.05), the average diameter of dilated vessels decreased and the average depth of dilated vessels increased (p0.05). In this study, the noninvasive measurement of PWS structure and optical parameters by Oct is realized. The results show that it is feasible to take the changes of PWS parameters before and after PDT treatment as the reference basis for evaluating the therapeutic effect and adjusting the treatment plan.
【作者单位】：北京理工大学信息与电子学院;中国人民解放军总医院激光医学科;清华大学物理系;
【基金】：国家自然科学基金(61036014,60878055) 国家高技术研究发展计划(2008AA030117) 国家卫计委公益性行业科研专项项目子课题(2015SQ00057)
【分类号】：R758.51

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