梅毒血清固定可能影响因素的Meta分析

发布时间：2018-07-09 15:13

  本文选题：血清固定 + 梅毒　； 参考：《中国卫生统计》2014年04期

【摘要】：目的梅毒血清固定潜在的影响因素阻碍其有效防治,对可能的影响因素进行Meta分析,能为其防治提供临床证据。方法检索Pubmed、Google Scholar、CNKI、万方数据库、重庆维普(VIP)、中国生物医学文献数据库(CBMDisc)。纳入标准:血清固定的诊断标准明确;以梅毒血清固定的影响因素为研究目的;HIV抗体检测阴性,女性为非妊娠或哺乳期妇女;研究结局为血清固定,对照为血清治愈组或健康对照组;语种限制为中文和英文。排除标准:资料不全或无法获取全文;重复报告;病例报告;缺乏对照;与研究目的不符;血清固定治疗;梅毒合并HIV;系统综述。计数资料用风险比(RR),计量资料采用标准化均数差(SMD)。数据的统计分析采用RevMan 5.1、SAS 9.0软件。结果最初共检索到1129篇文献,最终纳入25篇文献,涉及5153例梅毒患者。不同年龄段(RR≥40岁vs≤24岁=2.53,95%CI:1.53~4.19;RR≥40岁vs 25~39岁=1.99,95%CI:1.32~3.01)、性别(RR女vs男=1.5,95%CI:1.26~1.79)、梅毒临床分期(RR潜伏vs一期=3.34,95%CI:2.71~4.13;RR潜伏vs二期=2.17,95%CI:1.56~3.03)、血清初始滴度(RR1:32 vs≤1:32=0.15,95%CI:0.11~0.20)、治疗方式(RR非青霉素vs青霉素=2.20,95%CI:1.12~4.33)血清固定风险存有差异。血清固定患者外周血CD3、CD4、CD8及血清中IL-10水平与健康对照组和血清治愈组相比存在差异。此外,有文献提示TP重复基因型分型(RRi亚型vs d亚型=4.67,95%CI:1.31~16.69)、TP隐匿感染(RRFTA-Abs TP(+)vs FTA-Abs TP(-)=3.27,95%CI:2.89~3.69;RRTPPA-TP(+)vs TPPA-TP(-)=3.26,95%CI:2.89~3.68)可能与梅毒血清固定有关。结论至今有关梅毒血清固定还没有被广泛认可的确切定义,其机理也基本不清。年龄越大、女性、潜伏梅毒、血清初始滴度较低、非青霉素治疗及机体细胞免疫抑制及紊乱可能是梅毒血清固定的危险因素。梅毒血清固定有效防治策略应该针对潜在的各个影响因素来制定。
[Abstract]:Objective to provide clinical evidence for the prevention and treatment of syphilis by meta-analysis of the possible influencing factors. Methods We searched Pubmedus Scholararum CNKI, Wanfang database, VIP in Chongqing and CBMDisc in Chinese biomedical literature database. Inclusion criteria: the diagnostic criteria for serum fixation were clear; HIV antibodies were negative and women were non-pregnant or lactating women; serum fixation was the outcome of the study. The control group was serum cured group or healthy control group, and the language limitation was Chinese and English. Exclusion criteria: incomplete or inaccessible data; repeated reports; case reports; lack of control; inconsistent with the purpose of the study; serofixation; syphilis with HIV; systematic review. Risk ratio (RR) and standardized mean difference (SMD) were used for counting data. The data were analyzed by Revman 5.1 SAS 9.0 software. Results A total of 1129 articles were initially retrieved, and 25 papers were included, involving 5153 syphilis patients. Clinical stages of syphilis (RR 鈮，

本文编号：2109771