糖皮质激素联合免疫球蛋白治疗中毒性表皮坏死松解症25例临床观察

发布时间：2018-07-29 17:32

【摘要】：目的探讨糖皮质激素联合免疫球蛋白在中毒性表皮坏死松解症患者中的应用效果。方法选取2010年5月-2016年3月本院收治的中毒性表皮坏死松解症患者25例,依据入院时间分为治疗组(2013年5月-2016年3月,甲泼尼龙+免疫球蛋白)和对照组(2010年5月-2013年4月,甲泼尼龙),比较两组患者的临床疗效、药物作用时间、住院时间和不良反应。结果治疗组13例,有效率92.31%,对照组12例,有效率75.00%,差异有统计学意义(P0.05)。治疗组起效时间、退热时间、开始显效时间、糖皮质激素减量时间和住院时间均明显低于对照组,差异均有统计学意义(P均0.05)。治疗组口腔感染和血糖升高各1例,发生率15.38%,对照组口腔感染、肺部感染和皮肤感染各1例,血糖升高2例,发生率41.67%。结论糖皮质激素联合免疫球蛋白在治疗中毒性表皮坏死松解症成效显著,能够明显改善糜烂、水疱症状,具有起效快、安全性高的特点。
[Abstract]:Objective to investigate the effect of glucocorticoid combined with immunoglobulin in patients with toxic epidermal necrolysis. Methods from May 2010 to March 2016, 25 patients with toxic epidermal necrolysis were divided into treatment group (May 2013-March 2016, methylprednisolone immunoglobulin) and control group (May 2010 to April 2013). Methylprednisolone was used to compare the clinical efficacy, duration of drug action, hospital stay and adverse reactions between the two groups. Results the effective rate was 92.31% in the treatment group and 75.00% in the control group (P0.05). The onset time, antipyretic time, onset time, glucocorticoid reduction time and hospitalization time in the treatment group were significantly lower than those in the control group (P 0.05). There were 1 case of oral infection and 1 case of hyperglycemia in the treatment group, 1 case in the control group, 1 case in the lung infection and 1 case in the skin infection, and 2 cases in the hyperglycemia group (41.67%). Conclusion glucocorticoid combined with immunoglobulin is effective in the treatment of toxic epidermal necrolysis and can obviously improve the symptoms of erosion and blister.
【作者单位】：重庆市中医院皮肤科;
【分类号】：R758.59

【相似文献】