钙泊三醇倍他米松乳膏与卡泊三醇软膏序贯治疗银屑病

发布时间：2018-08-07 21:09

【摘要】：目的:观察钙泊三醇倍他米松乳膏与卡泊三醇软膏序贯治疗银屑病患者的疗效及安全性。方法:将90例斑块状寻常性银屑病患者随机分为3组,第一组:外用钙泊三醇倍他米松乳膏4周(每日1次)+钙泊三醇倍他米松乳膏与卡泊三醇软膏交替使用2周(均每日1次,2种交替)+卡泊三醇软膏6周(每日1次);第二组:外用钙泊三醇倍他米松软膏6周+卡泊三醇软膏6周(均每日1次);第三组:外用卡泊三醇软膏12周(每日2次)。结果:3组患者治疗4、6、12周后银屑病皮损面积和严重程度指数(PASI)评分分别与各组治疗前比较,差异均有统计学意义(P均0.05)。第一组与第二组疗效均优于第三组,差异均有统计学意义(P均0.05),但第一组与第二组疗效比较,差异无统计学意义(P0.05)。结论:序贯疗法起效快且疗效优,为患者节省医疗开支并减少糖皮质激素的不良反应。
[Abstract]:Objective: to observe the efficacy and safety of calcium-betamethasone cream and carpotriol ointment in the treatment of psoriasis. Methods: 90 patients with plaque psoriasis vulgaris were randomly divided into 3 groups. Group 1: topical betamethasone cream for 4 weeks (once a day) and carpotriol ointment alternately for 2 weeks (1 / d) for 6 weeks (1 / d) Group 2: carpotriol ointment for 6 weeks (once a day), group 3: carpotriol ointment for 12 weeks (2 times a day); group 2: external use of carpotriol betamethasone ointment for 6 weeks (once a day); group 3: external use of carpotriol ointment for 12 weeks (2 times a day). Results the (PASI) scores of psoriasis lesion area and severity index were significantly different from those before treatment (P 0.05). The first group and the second group were better than the third group, the difference was statistically significant (P 0.05), but the first group and the second group, the difference was not statistically significant (P0.05). Conclusion: sequential therapy is effective and effective. It can save medical expenses and reduce adverse reaction of glucocorticoid.
【作者单位】：中国人民解放军第404医院皮肤科;
【分类号】：R758.63

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